UBE1L

UBE1L

Ubiquitin-activating enzyme E1-like, also known as UBE1L, is a human gene.cite web | title = Entrez Gene: UBE1L ubiquitin-activating enzyme E1-like| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7318| accessdate = ]

PBB_Summary
section_title =
summary_text = The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia.cite web | title = Entrez Gene: UBE1L ubiquitin-activating enzyme E1-like| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7318| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Carritt B, Kok K, van den Berg A, "et al." |title=A gene from human chromosome region 3p21 with reduced expression in small cell lung cancer. |journal=Cancer Res. |volume=52 |issue= 6 |pages= 1536–41 |year= 1992 |pmid= 1311632 |doi=
*cite journal | author=Kok K, Van den Berg A, Veldhuis PM, "et al." |title=The genomic structure of the human UBE1L gene. |journal=Gene Expr. |volume=4 |issue= 3 |pages= 163–75 |year= 1995 |pmid= 7734949 |doi=
*cite journal | author=Kok K, Hofstra R, Pilz A, "et al." |title=A gene in the chromosomal region 3p21 with greatly reduced expression in lung cancer is similar to the gene for ubiquitin-activating enzyme. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 13 |pages= 6071–5 |year= 1993 |pmid= 8327486 |doi=
*cite journal | author=McLaughlin PM, Helfrich W, Kok K, "et al." |title=The ubiquitin-activating enzyme E1-like protein in lung cancer cell lines. |journal=Int. J. Cancer |volume=85 |issue= 6 |pages= 871–6 |year= 2000 |pmid= 10709110 |doi=
*cite journal | author=Yuan W, Krug RM |title=Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)-induced ubiquitin-like ISG15 protein. |journal=EMBO J. |volume=20 |issue= 3 |pages= 362–71 |year= 2001 |pmid= 11157743 |doi= 10.1093/emboj/20.3.362
*cite journal | author=Kitareewan S, Pitha-Rowe I, Sekula D, "et al." |title=UBE1L is a retinoid target that triggers PML/RARalpha degradation and apoptosis in acute promyelocytic leukemia. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 6 |pages= 3806–11 |year= 2002 |pmid= 11891284 |doi= 10.1073/pnas.052011299
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gevaert K, Goethals M, Martens L, "et al." |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810
*cite journal | author=Pitha-Rowe I, Hassel BA, Dmitrovsky E |title=Involvement of UBE1L in ISG15 conjugation during retinoid-induced differentiation of acute promyelocytic leukemia. |journal=J. Biol. Chem. |volume=279 |issue= 18 |pages= 18178–87 |year= 2004 |pmid= 14976209 |doi= 10.1074/jbc.M309259200
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Lenschow DJ, Giannakopoulos NV, Gunn LJ, "et al." |title=Identification of interferon-stimulated gene 15 as an antiviral molecule during Sindbis virus infection in vivo. |journal=J. Virol. |volume=79 |issue= 22 |pages= 13974–83 |year= 2006 |pmid= 16254333 |doi= 10.1128/JVI.79.22.13974-13983.2005
*cite journal | author=Takeuchi T, Iwahara S, Saeki Y, "et al." |title=Link between the Ubiquitin Conjugation System and the ISG15 Conjugation System: ISG15 Conjugation to the UbcH6 Ubiquitin E2 Enzyme. |journal=J. Biochem. |volume=138 |issue= 6 |pages= 711–9 |year= |pmid= 16428300 |doi= 10.1093/jb/mvi172

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes


Wikimedia Foundation. 2010.

Игры ⚽ Поможем написать реферат

Look at other dictionaries:

  • Breakthrough of the Year — The Breakthrough of the Year is an annual award made by the journal Science for the most significant development in scientific research. Originating in 1989 as the Molecule of the Year, inspired by Time s Man of the Year, it was renamed the… …   Wikipedia

  • ISG15 — ubiquitin like modifier, also known as ISG15, is a human gene. [cite web | title = Entrez Gene: ISG15 ISG15 ubiquitin like modifier| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=9636| accessdate = ] ISG15 …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”