UBE1C

Ubiquitin-activating enzyme E1C (UBA3 homolog, yeast), also known as UBE1C, is a human gene.cite web | title = Entrez Gene: UBE1C ubiquitin-activating enzyme E1C (UBA3 homolog, yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9039| accessdate = ]

PBB_Summary
section_title =
summary_text = The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.cite web | title = Entrez Gene: UBE1C ubiquitin-activating enzyme E1C (UBA3 homolog, yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9039| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Osaka F, Kawasaki H, Aida N, "et al." |title=A new NEDD8-ligating system for cullin-4A. |journal=Genes Dev. |volume=12 |issue= 15 |pages= 2263–8 |year= 1998 |pmid= 9694792 |doi=
*cite journal | author=Gong L, Yeh ET |title=Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway. |journal=J. Biol. Chem. |volume=274 |issue= 17 |pages= 12036–42 |year= 1999 |pmid= 10207026 |doi=
*cite journal | author=Gubin AN, Njoroge JM, Bouffard GG, Miller JL |title=Gene expression in proliferating human erythroid cells. |journal=Genomics |volume=59 |issue= 2 |pages= 168–77 |year= 1999 |pmid= 10409428 |doi= 10.1006/geno.1999.5855
*cite journal | author=Chen Y, McPhie DL, Hirschberg J, Neve RL |title=The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons. |journal=J. Biol. Chem. |volume=275 |issue= 12 |pages= 8929–35 |year= 2000 |pmid= 10722740 |doi=
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=
*cite journal | author=Wiemann S, Weil B, Wellenreuther R, "et al." |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701
*cite journal | author=Simpson JC, Wellenreuther R, Poustka A, "et al." |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Walden H, Podgorski MS, Schulman BA |title=Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8. |journal=Nature |volume=422 |issue= 6929 |pages= 330–4 |year= 2003 |pmid= 12646924 |doi= 10.1038/nature01456
*cite journal | author=Bohnsack RN, Haas AL |title=Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer. |journal=J. Biol. Chem. |volume=278 |issue= 29 |pages= 26823–30 |year= 2003 |pmid= 12740388 |doi= 10.1074/jbc.M303177200
*cite journal | author=Walden H, Podgorski MS, Huang DT, "et al." |title=The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1. |journal=Mol. Cell |volume=12 |issue= 6 |pages= 1427–37 |year= 2004 |pmid= 14690597 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Huang DT, Miller DW, Mathew R, "et al." |title=A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8. |journal=Nat. Struct. Mol. Biol. |volume=11 |issue= 10 |pages= 927–35 |year= 2004 |pmid= 15361859 |doi= 10.1038/nsmb826
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Wiemann S, Arlt D, Huber W, "et al." |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704
*cite journal | author=Huang DT, Paydar A, Zhuang M, "et al." |title=Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1. |journal=Mol. Cell |volume=17 |issue= 3 |pages= 341–50 |year= 2005 |pmid= 15694336 |doi= 10.1016/j.molcel.2004.12.020
*cite journal | author=Mehrle A, Rosenfelder H, Schupp I, "et al." |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139
*cite journal | author=Hiller M, Huse K, Szafranski K, "et al." |title=Single-nucleotide polymorphisms in NAGNAG acceptors are highly predictive for variations of alternative splicing. |journal=Am. J. Hum. Genet. |volume=78 |issue= 2 |pages= 291–302 |year= 2007 |pmid= 16400609 |doi= 10.1086/500151
*cite journal | author=Norman JA, Shiekhattar R |title=Analysis of Nedd8-associated polypeptides: a model for deciphering the pathway for ubiquitin-like modifications. |journal=Biochemistry |volume=45 |issue= 9 |pages= 3014–9 |year= 2006 |pmid= 16503656 |doi= 10.1021/bi052435a
*cite journal | author=Li T, Santockyte R, Shen RF, "et al." |title=A general approach for investigating enzymatic pathways and substrates for ubiquitin-like modifiers. |journal=Arch. Biochem. Biophys. |volume=453 |issue= 1 |pages= 70–4 |year= 2006 |pmid= 16620772 |doi= 10.1016/j.abb.2006.03.002

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