APPBP1

Amyloid beta precursor protein binding protein 1, also known as APPBP1, is a human gene.cite web | title = Entrez Gene: APPBP1 amyloid beta precursor protein binding protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8883| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene.cite web | title = Entrez Gene: APPBP1 amyloid beta precursor protein binding protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8883| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Chow N, Korenberg JR, Chen XN, Neve RL |title=APP-BP1, a novel protein that binds to the carboxyl-terminal region of the amyloid precursor protein. |journal=J. Biol. Chem. |volume=271 |issue= 19 |pages= 11339–46 |year= 1996 |pmid= 8626687 |doi=
*cite journal | author=Gong L, Yeh ET |title=Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway. |journal=J. Biol. Chem. |volume=274 |issue= 17 |pages= 12036–42 |year= 1999 |pmid= 10207026 |doi=
*cite journal | author=Loftus BJ, Kim UJ, Sneddon VP, "et al." |title=Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. |journal=Genomics |volume=60 |issue= 3 |pages= 295–308 |year= 1999 |pmid= 10493829 |doi= 10.1006/geno.1999.5927
*cite journal | author=Hori T, Osaka F, Chiba T, "et al." |title=Covalent modification of all members of human cullin family proteins by NEDD8. |journal=Oncogene |volume=18 |issue= 48 |pages= 6829–34 |year= 2000 |pmid= 10597293 |doi= 10.1038/sj.onc.1203093
*cite journal | author=Chen Y, McPhie DL, Hirschberg J, Neve RL |title=The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons. |journal=J. Biol. Chem. |volume=275 |issue= 12 |pages= 8929–35 |year= 2000 |pmid= 10722740 |doi=
*cite journal | author=Wiemann S, Weil B, Wellenreuther R, "et al." |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Walden H, Podgorski MS, Schulman BA |title=Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8. |journal=Nature |volume=422 |issue= 6929 |pages= 330–4 |year= 2003 |pmid= 12646924 |doi= 10.1038/nature01456
*cite journal | author=Chen Y, Liu W, Naumovski L, Neve RL |title=ASPP2 inhibits APP-BP1-mediated NEDD8 conjugation to cullin-1 and decreases APP-BP1-induced cell proliferation and neuronal apoptosis. |journal=J. Neurochem. |volume=85 |issue= 3 |pages= 801–9 |year= 2003 |pmid= 12694406 |doi=
*cite journal | author=Bohnsack RN, Haas AL |title=Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer. |journal=J. Biol. Chem. |volume=278 |issue= 29 |pages= 26823–30 |year= 2003 |pmid= 12740388 |doi= 10.1074/jbc.M303177200
*cite journal | author=Chen Y, Liu W, McPhie DL, "et al." |title=APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain. |journal=J. Cell Biol. |volume=163 |issue= 1 |pages= 27–33 |year= 2003 |pmid= 14557245 |doi= 10.1083/jcb.200304003
*cite journal | author=Walden H, Podgorski MS, Huang DT, "et al." |title=The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1. |journal=Mol. Cell |volume=12 |issue= 6 |pages= 1427–37 |year= 2004 |pmid= 14690597 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Huang DT, Miller DW, Mathew R, "et al." |title=A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8. |journal=Nat. Struct. Mol. Biol. |volume=11 |issue= 10 |pages= 927–35 |year= 2004 |pmid= 15361859 |doi= 10.1038/nsmb826
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Oh JH, Yang JO, Hahn Y, "et al." |title=Transcriptome analysis of human gastric cancer. |journal=Mamm. Genome |volume=16 |issue= 12 |pages= 942–54 |year= 2006 |pmid= 16341674 |doi= 10.1007/s00335-005-0075-2
*cite journal | author=Hiller M, Huse K, Szafranski K, "et al." |title=Single-nucleotide polymorphisms in NAGNAG acceptors are highly predictive for variations of alternative splicing. |journal=Am. J. Hum. Genet. |volume=78 |issue= 2 |pages= 291–302 |year= 2007 |pmid= 16400609 |doi= 10.1086/500151
*cite journal | author=Norman JA, Shiekhattar R |title=Analysis of Nedd8-associated polypeptides: a model for deciphering the pathway for ubiquitin-like modifications. |journal=Biochemistry |volume=45 |issue= 9 |pages= 3014–9 |year= 2006 |pmid= 16503656 |doi= 10.1021/bi052435a
*cite journal | author=Li T, Santockyte R, Shen RF, "et al." |title=A general approach for investigating enzymatic pathways and substrates for ubiquitin-like modifiers. |journal=Arch. Biochem. Biophys. |volume=453 |issue= 1 |pages= 70–4 |year= 2006 |pmid= 16620772 |doi= 10.1016/j.abb.2006.03.002

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