UBE2M

Ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast), also known as UBE2M, is a human gene.cite web | title = Entrez Gene: UBE2M ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9040| accessdate = ]

PBB_Summary
section_title =
summary_text = The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is linked with a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin.cite web | title = Entrez Gene: UBE2M ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9040| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Osaka F, Kawasaki H, Aida N, "et al." |title=A new NEDD8-ligating system for cullin-4A. |journal=Genes Dev. |volume=12 |issue= 15 |pages= 2263–8 |year= 1998 |pmid= 9694792 |doi=
*cite journal | author=Gong L, Yeh ET |title=Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway. |journal=J. Biol. Chem. |volume=274 |issue= 17 |pages= 12036–42 |year= 1999 |pmid= 10207026 |doi=
*cite journal | author=Chen Y, McPhie DL, Hirschberg J, Neve RL |title=The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons. |journal=J. Biol. Chem. |volume=275 |issue= 12 |pages= 8929–35 |year= 2000 |pmid= 10722740 |doi=
*cite journal | author=Wada H, Yeh ET, Kamitani T |title=A dominant-negative UBC12 mutant sequesters NEDD8 and inhibits NEDD8 conjugation in vivo. |journal=J. Biol. Chem. |volume=275 |issue= 22 |pages= 17008–15 |year= 2000 |pmid= 10828074 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Tomsig JL, Snyder SL, Creutz CE |title=Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif. |journal=J. Biol. Chem. |volume=278 |issue= 12 |pages= 10048–54 |year= 2003 |pmid= 12522145 |doi= 10.1074/jbc.M212632200
*cite journal | author=Huang DT, Miller DW, Mathew R, "et al." |title=A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8. |journal=Nat. Struct. Mol. Biol. |volume=11 |issue= 10 |pages= 927–35 |year= 2004 |pmid= 15361859 |doi= 10.1038/nsmb826
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Huang DT, Paydar A, Zhuang M, "et al." |title=Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1. |journal=Mol. Cell |volume=17 |issue= 3 |pages= 341–50 |year= 2005 |pmid= 15694336 |doi= 10.1016/j.molcel.2004.12.020
*cite journal | author=Li T, Santockyte R, Shen RF, "et al." |title=A general approach for investigating enzymatic pathways and substrates for ubiquitin-like modifiers. |journal=Arch. Biochem. Biophys. |volume=453 |issue= 1 |pages= 70–4 |year= 2006 |pmid= 16620772 |doi= 10.1016/j.abb.2006.03.002
*cite journal | author=Ewing RM, Chu P, Elisma F, "et al." |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134

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