USP2

Ubiquitin specific peptidase 2, also known as USP2, is a human gene.cite web | title = Entrez Gene: USP2 ubiquitin specific peptidase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9099| accessdate = ]

PBB_Summary
section_title =
summary_text = Ubiquitin (MIM 191339), a highly conserved protein involved in the regulation of intracellular protein breakdown, cell cycle regulation, and stress response, is released from degraded proteins by disassembly of the polyubiquitin chains. The disassembly process is mediated by ubiquitin-specific proteases (USPs). Also see USP1 (MIM 603478). [supplied by OMIM] cite web | title = Entrez Gene: USP2 ubiquitin specific peptidase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9099| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=D'Andrea A, Pellman D |title=Deubiquitinating enzymes: a new class of biological regulators. |journal=Crit. Rev. Biochem. Mol. Biol. |volume=33 |issue= 5 |pages= 337–52 |year= 1999 |pmid= 9827704 |doi=
*cite journal | author=Puente XS, Sánchez LM, Overall CM, López-Otín C |title=Human and mouse proteases: a comparative genomic approach. |journal=Nat. Rev. Genet. |volume=4 |issue= 7 |pages= 544–58 |year= 2003 |pmid= 12838346 |doi= 10.1038/nrg1111
*cite journal | author=Baek SH, Choi KS, Yoo YJ, "et al." |title=Molecular cloning of a novel ubiquitin-specific protease, UBP41, with isopeptidase activity in chick skeletal muscle. |journal=J. Biol. Chem. |volume=272 |issue= 41 |pages= 25560–5 |year= 1997 |pmid= 9325273 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gewies A, Grimm S |title=UBP41 is a proapoptotic ubiquitin-specific protease. |journal=Cancer Res. |volume=63 |issue= 3 |pages= 682–8 |year= 2003 |pmid= 12566314 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Bouwmeester T, Bauch A, Ruffner H, "et al." |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97–105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086
*cite journal | author=Graner E, Tang D, Rossi S, "et al." |title=The isopeptidase USP2a regulates the stability of fatty acid synthase in prostate cancer. |journal=Cancer Cell |volume=5 |issue= 3 |pages= 253–61 |year= 2004 |pmid= 15050917 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Stevenson LF, Sparks A, Allende-Vega N, "et al." |title=The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2. |journal=EMBO J. |volume=26 |issue= 4 |pages= 976–86 |year= 2007 |pmid= 17290220 |doi= 10.1038/sj.emboj.7601567

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