HSPA4

Heat shock 70kDa protein 4, also known as HSPA4, is a human gene.cite web | title = Entrez Gene: HSPA4 heat shock 70kDa protein 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3308| accessdate = ]

The protein encoded by this gene was originally suggested to be a member of the heat shock protein 70 family.cite journal | author = Fathallah DM, Cherif D, Dellagi K, Arnaout MA | title = Molecular cloning of a novel human hsp70 from a B cell line and its assignment to chromosome 5 | journal = J. Immunol. | volume = 151 | issue = 2 | pages = 810–3 | year = 1993 | month = July | pmid = 8335910 | doi = | url = http://www.jimmunol.org/cgi/pmidlookup?view=long&pmid=8335910 | issn = ] However it is now known that human HSPA4 is a equivalent to mouse the Apg-2 protein and is a member of the Hsp110 family.cite journal | author = Kaneko Y, Kimura T, Kishishita M, Noda Y, Fujita J | title = Cloning of apg-2 encoding a novel member of heat shock protein 110 family | journal = Gene | volume = 189 | issue = 1 | pages = 19–24 | year = 1997 | month = April | pmid = 9161406 | doi = 10.1016/S0378-1119(96)00807-4 | url = | issn = ]

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References

Further reading

PBB_Further_reading
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*cite journal | author=Abravaya K, Myers MP, Murphy SP, Morimoto RI |title=The human heat shock protein hsp70 interacts with HSF, the transcription factor that regulates heat shock gene expression. |journal=Genes Dev. |volume=6 |issue= 7 |pages= 1153–64 |year= 1992 |pmid= 1628823 |doi=
*cite journal | author=Liao J, Lowthert LA, Ghori N, Omary MB |title=The 70-kDa heat shock proteins associate with glandular intermediate filaments in an ATP-dependent manner. |journal=J. Biol. Chem. |volume=270 |issue= 2 |pages= 915–22 |year= 1995 |pmid= 7529764 |doi=
*cite journal | author=Furlini G, Vignoli M, Re MC, "et al." |title=Human immunodeficiency virus type 1 interaction with the membrane of CD4+ cells induces the synthesis and nuclear translocation of 70K heat shock protein. |journal=J. Gen. Virol. |volume=75 ( Pt 1) |issue= |pages= 193–9 |year= 1994 |pmid= 7906708 |doi=
*cite journal | author=Fathallah DM, Cherif D, Dellagi K, Arnaout MA |title=Molecular cloning of a novel human hsp70 from a B cell line and its assignment to chromosome 5. |journal=J. Immunol. |volume=151 |issue= 2 |pages= 810–3 |year= 1993 |pmid= 8335910 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Schulte AM, Fischer S, Sachse GE, "et al." |title=Identification and characterization of a novel hsc70-like gene in the human lung tumor cell line HS24. |journal=DNA Cell Biol. |volume=16 |issue= 3 |pages= 257–68 |year= 1997 |pmid= 9115634 |doi=
*cite journal | author=Kaneko Y, Kimura T, Kishishita M, "et al." |title=Cloning of apg-2 encoding a novel member of heat shock protein 110 family. |journal=Gene |volume=189 |issue= 1 |pages= 19–24 |year= 1997 |pmid= 9161406 |doi=
*cite journal | author=Bruner KL, Derfoul A, Robertson NM, "et al." |title=The unliganded mineralocorticoid receptor is associated with heat shock proteins 70 and 90 and the immunophilin FKBP-52. |journal=Receptors & signal transduction |volume=7 |issue= 2 |pages= 85–98 |year= 1998 |pmid= 9392437 |doi=
*cite journal | author=Satyal SH, Chen D, Fox SG, "et al." |title=Negative regulation of the heat shock transcriptional response by HSBP1. |journal=Genes Dev. |volume=12 |issue= 13 |pages= 1962–74 |year= 1998 |pmid= 9649501 |doi=
*cite journal | author=Naylor DJ, Stines AP, Hoogenraad NJ, Høj PB |title=Evidence for the existence of distinct mammalian cytosolic, microsomal, and two mitochondrial GrpE-like proteins, the Co-chaperones of specific Hsp70 members. |journal=J. Biol. Chem. |volume=273 |issue= 33 |pages= 21169–77 |year= 1998 |pmid= 9694873 |doi=
*cite journal | author=Melville MW, Tan SL, Wambach M, "et al." |title=The cellular inhibitor of the PKR protein kinase, P58(IPK), is an influenza virus-activated co-chaperone that modulates heat shock protein 70 activity. |journal=J. Biol. Chem. |volume=274 |issue= 6 |pages= 3797–803 |year= 1999 |pmid= 9920933 |doi=
*cite journal | author=Ballinger CA, Connell P, Wu Y, "et al." |title=Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions. |journal=Mol. Cell. Biol. |volume=19 |issue= 6 |pages= 4535–45 |year= 1999 |pmid= 10330192 |doi=
*cite journal | author=Liu H, Vuyyuru VB, Pham CD, "et al." |title=Evidence of an interaction between Mos and Hsp70: a role of the Mos residue serine 3 in mediating Hsp70 association. |journal=Oncogene |volume=18 |issue= 23 |pages= 3461–70 |year= 1999 |pmid= 10376524 |doi= 10.1038/sj.onc.1202699
*cite journal | author=Nonoguchi K, Itoh K, Xue JH, "et al." |title=Cloning of human cDNAs for Apg-1 and Apg-2, members of the Hsp110 family, and chromosomal assignment of their genes. |journal=Gene |volume=237 |issue= 1 |pages= 21–8 |year= 1999 |pmid= 10524232 |doi=
*cite journal | author=O'Keeffe B, Fong Y, Chen D, "et al." |title=Requirement for a kinase-specific chaperone pathway in the production of a Cdk9/cyclin T1 heterodimer responsible for P-TEFb-mediated tat stimulation of HIV-1 transcription. |journal=J. Biol. Chem. |volume=275 |issue= 1 |pages= 279–87 |year= 2000 |pmid= 10617616 |doi=
*cite journal | author=Agostini I, Popov S, Li J, "et al." |title=Heat-shock protein 70 can replace viral protein R of HIV-1 during nuclear import of the viral preintegration complex. |journal=Exp. Cell Res. |volume=259 |issue= 2 |pages= 398–403 |year= 2000 |pmid= 10964507 |doi= 10.1006/excr.2000.4992
*cite journal | author=Kim M, Jiang LH, Wilson HL, "et al." |title=Proteomic and functional evidence for a P2X7 receptor signalling complex. |journal=EMBO J. |volume=20 |issue= 22 |pages= 6347–58 |year= 2002 |pmid= 11707406 |doi= 10.1093/emboj/20.22.6347
*cite journal | author=Johnson CA, White DA, Lavender JS, "et al." |title=Human class I histone deacetylase complexes show enhanced catalytic activity in the presence of ATP and co-immunoprecipitate with the ATP-dependent chaperone protein Hsp70. |journal=J. Biol. Chem. |volume=277 |issue= 11 |pages= 9590–7 |year= 2002 |pmid= 11777905 |doi= 10.1074/jbc.M107942200
*cite journal | author=Gurer C, Cimarelli A, Luban J |title=Specific incorporation of heat shock protein 70 family members into primate lentiviral virions. |journal=J. Virol. |volume=76 |issue= 9 |pages= 4666–70 |year= 2002 |pmid= 11932435 |doi=
*cite journal | author=Freeman BC, Yamamoto KR |title=Disassembly of transcriptional regulatory complexes by molecular chaperones. |journal=Science |volume=296 |issue= 5576 |pages= 2232–5 |year= 2002 |pmid= 12077419 |doi= 10.1126/science.1073051

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