UBE2L3

Ubiquitin-conjugating enzyme E2L 3, also known as UBE2L3, is a human gene.cite web | title = Entrez Gene: UBE2L3 ubiquitin-conjugating enzyme E2L 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7332| accessdate = ]

PBB_Summary
section_title =
summary_text = The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in vitro. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.cite web | title = Entrez Gene: UBE2L3 ubiquitin-conjugating enzyme E2L 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7332| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Blumenfeld N, Gonen H, Mayer A, "et al." |title=Purification and characterization of a novel species of ubiquitin-carrier protein, E2, that is involved in degradation of non-"N-end rule" protein substrates. |journal=J. Biol. Chem. |volume=269 |issue= 13 |pages= 9574–81 |year= 1994 |pmid= 8144544 |doi=
*cite journal | author=Robinson PA, Leek JP, Thompson J, "et al." |title=A human ubiquitin conjugating enzyme, L-UBC, maps in the Alzheimer's disease locus on chromosome 14q24.3. |journal=Mamm. Genome |volume=6 |issue= 10 |pages= 725–31 |year= 1996 |pmid= 8563171 |doi=
*cite journal | author=Nuber U, Schwarz S, Kaiser P, "et al." |title=Cloning of human ubiquitin-conjugating enzymes UbcH6 and UbcH7 (E2-F1) and characterization of their interaction with E6-AP and RSP5. |journal=J. Biol. Chem. |volume=271 |issue= 5 |pages= 2795–800 |year= 1996 |pmid= 8576257 |doi=
*cite journal | author=Moynihan TP, Ardley HC, Leek JP, "et al." |title=Characterization of a human ubiquitin-conjugating enzyme gene UBE2L3. |journal=Mamm. Genome |volume=7 |issue= 7 |pages= 520–5 |year= 1996 |pmid= 8672131 |doi=
*cite journal | author=Kumar S, Kao WH, Howley PM |title=Physical interaction between specific E2 and Hect E3 enzymes determines functional cooperativity. |journal=J. Biol. Chem. |volume=272 |issue= 21 |pages= 13548–54 |year= 1997 |pmid= 9153201 |doi=
*cite journal | author=Moynihan TP, Cole CG, Dunham I, "et al." |title=Fine-mapping, genomic organization, and transcript analysis of the human ubiquitin-conjugating enzyme gene UBE2L3. |journal=Genomics |volume=51 |issue= 1 |pages= 124–7 |year= 1998 |pmid= 9693040 |doi= 10.1006/geno.1998.5257
*cite journal | author=Anan T, Nagata Y, Koga H, "et al." |title=Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes. |journal=Genes Cells |volume=3 |issue= 11 |pages= 751–63 |year= 1999 |pmid= 9990509 |doi=
*cite journal | author=Martinez-Noel G, Niedenthal R, Tamura T, Harbers K |title=A family of structurally related RING finger proteins interacts specifically with the ubiquitin-conjugating enzyme UbcM4. |journal=FEBS Lett. |volume=454 |issue= 3 |pages= 257–61 |year= 1999 |pmid= 10431818 |doi=
*cite journal | author=Moynihan TP, Ardley HC, Nuber U, "et al." |title=The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1. |journal=J. Biol. Chem. |volume=274 |issue= 43 |pages= 30963–8 |year= 1999 |pmid= 10521492 |doi=
*cite journal | author=Yokouchi M, Kondo T, Houghton A, "et al." |title=Ligand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and UbcH7. |journal=J. Biol. Chem. |volume=274 |issue= 44 |pages= 31707–12 |year= 1999 |pmid= 10531381 |doi=
*cite journal | author=Huang L, Kinnucan E, Wang G, "et al." |title=Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade. |journal=Science |volume=286 |issue= 5443 |pages= 1321–6 |year= 1999 |pmid= 10558980 |doi=
*cite journal | author=Ardley HC, Moynihan TP, Markham AF, Robinson PA |title=Promoter analysis of the human ubiquitin-conjugating enzyme gene family UBE2L1-4, including UBE2L3 which encodes UbcH7. |journal=Biochim. Biophys. Acta |volume=1491 |issue= 1-3 |pages= 57–64 |year= 2000 |pmid= 10760570 |doi=
*cite journal | author=Zheng N, Wang P, Jeffrey PD, Pavletich NP |title=Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases. |journal=Cell |volume=102 |issue= 4 |pages= 533–9 |year= 2000 |pmid= 10966114 |doi=
*cite journal | author=Zhang Y, Gao J, Chung KK, "et al." |title=Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 24 |pages= 13354–9 |year= 2001 |pmid= 11078524 |doi= 10.1073/pnas.240347797
*cite journal | author=Niwa J, Ishigaki S, Doyu M, "et al." |title=A novel centrosomal ring-finger protein, dorfin, mediates ubiquitin ligase activity. |journal=Biochem. Biophys. Res. Commun. |volume=281 |issue= 3 |pages= 706–13 |year= 2001 |pmid= 11237715 |doi= 10.1006/bbrc.2001.4414
*cite journal | author=Pringa E, Martinez-Noel G, Muller U, Harbers K |title=Interaction of the ring finger-related U-box motif of a nuclear dot protein with ubiquitin-conjugating enzymes. |journal=J. Biol. Chem. |volume=276 |issue= 22 |pages= 19617–23 |year= 2001 |pmid= 11274149 |doi= 10.1074/jbc.M100192200
*cite journal | author=Ardley HC, Tan NG, Rose SA, "et al." |title=Features of the parkin/ariadne-like ubiquitin ligase, HHARI, that regulate its interaction with the ubiquitin-conjugating enzyme, Ubch7. |journal=J. Biol. Chem. |volume=276 |issue= 22 |pages= 19640–7 |year= 2001 |pmid= 11278816 |doi= 10.1074/jbc.M011028200
*cite journal | author=Obin M, Lee BY, Meinke G, "et al." |title=Ubiquitylation of the transducin betagamma subunit complex. Regulation by phosducin. |journal=J. Biol. Chem. |volume=277 |issue= 46 |pages= 44566–75 |year= 2003 |pmid= 12215439 |doi= 10.1074/jbc.M205308200
*cite journal | author=Wong ES, Fong CW, Lim J, "et al." |title=Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling. |journal=EMBO J. |volume=21 |issue= 18 |pages= 4796–808 |year= 2002 |pmid= 12234920 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899

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