RNF19A

Ring finger protein 19, also known as RNF19, is a human gene.cite web | title = Entrez Gene: RNF19 ring finger protein 19| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25897| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded this gene contains two RING-finger motifs and an IBR (in between RING fingers) motif. This protein is an E3 ubiquintin ligase that is localized in Lewy bodies (LBs), a characteristic neuronal inclusion in Parkinson's disease (PD) brains. This protein interacts with UBE2L3/UBCH7 and UBE2E2/UBCH8, but not other ubiquitin-conjugating enzymes. This protein is found to bind and ubiquitylate synphilin 1 (SNCAIP), which is an interacting protein of alpha synuclein in neurons, and a major component of LB. Alternatively spliced transcript variants encoding the same protein have been reported.cite web | title = Entrez Gene: RNF19 ring finger protein 19| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25897| accessdate = ]

ee also

* RING finger domain

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Gunther M, Laithier M, Brison O |title=A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening. |journal=Mol. Cell. Biochem. |volume=210 |issue= 1-2 |pages= 131–42 |year= 2000 |pmid= 10976766 |doi=
*cite journal | author=Niwa J, Ishigaki S, Doyu M, "et al." |title=A novel centrosomal ring-finger protein, dorfin, mediates ubiquitin ligase activity. |journal=Biochem. Biophys. Res. Commun. |volume=281 |issue= 3 |pages= 706–13 |year= 2001 |pmid= 11237715 |doi= 10.1006/bbrc.2001.4414
*cite journal | author=Niwa J, Ishigaki S, Hishikawa N, "et al." |title=Dorfin ubiquitylates mutant SOD1 and prevents mutant SOD1-mediated neurotoxicity. |journal=J. Biol. Chem. |volume=277 |issue= 39 |pages= 36793–8 |year= 2002 |pmid= 12145308 |doi= 10.1074/jbc. M206559200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ito T, Niwa J, Hishikawa N, "et al." |title=Dorfin localizes to Lewy bodies and ubiquitylates synphilin-1. |journal=J. Biol. Chem. |volume=278 |issue= 31 |pages= 29106–14 |year= 2003 |pmid= 12750386 |doi= 10.1074/jbc. M302763200
*cite journal | author=Hishikawa N, Niwa J, Doyu M, "et al." |title=Dorfin localizes to the ubiquitylated inclusions in Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, and amyotrophic lateral sclerosis. |journal=Am. J. Pathol. |volume=163 |issue= 2 |pages= 609–19 |year= 2003 |pmid= 12875980 |doi=
*cite journal | author=Paces-Fessy M, Boucher D, Petit E, "et al." |title=The negative regulator of Gli, Suppressor of fused (Sufu), interacts with SAP18, Galectin3 and other nuclear proteins. |journal=Biochem. J. |volume=378 |issue= Pt 2 |pages= 353–62 |year= 2004 |pmid= 14611647 |doi= 10.1042/BJ20030786
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Takeuchi H, Niwa J, Hishikawa N, "et al." |title=Dorfin prevents cell death by reducing mitochondrial localizing mutant superoxide dismutase 1 in a neuronal cell model of familial amyotrophic lateral sclerosis. |journal=J. Neurochem. |volume=89 |issue= 1 |pages= 64–72 |year= 2004 |pmid= 15030390 |doi= 10.1046/j.1471-4159.2003.02289.x
*cite journal | author=Ishigaki S, Hishikawa N, Niwa J, "et al." |title=Physical and functional interaction between Dorfin and Valosin-containing protein that are colocalized in ubiquitylated inclusions in neurodegenerative disorders. |journal=J. Biol. Chem. |volume=279 |issue= 49 |pages= 51376–85 |year= 2005 |pmid= 15456787 |doi= 10.1074/jbc. M406683200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Huang Y, Niwa J, Sobue G, Breitwieser GE |title=Calcium-sensing receptor ubiquitination and degradation mediated by the E3 ubiquitin ligase dorfin. |journal=J. Biol. Chem. |volume=281 |issue= 17 |pages= 11610–7 |year= 2006 |pmid= 16513638 |doi= 10.1074/jbc. M513552200
*cite journal | author=Ishigaki S, Niwa J, Yamada S, "et al." |title=Dorfin-CHIP chimeric proteins potently ubiquitylate and degrade familial ALS-related mutant SOD1 proteins and reduce their cellular toxicity. |journal=Neurobiol. Dis. |volume=25 |issue= 2 |pages= 331–41 |year= 2007 |pmid= 17157513 |doi= 10.1016/j.nbd.2006.09.017

External links

*

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