UBE2V2

Ubiquitin-conjugating enzyme E2 variant 2, also known as UBE2V2, is a human gene.cite web | title = Entrez Gene: UBE2V2 ubiquitin-conjugating enzyme E2 variant 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7336| accessdate = ]

PBB_Summary
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summary_text = Ubiquitin-conjugating enzyme E2 variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene also shares homology with ubiquitin-conjugating enzyme E2 variant 1 and yeast MMS2 gene product. It may be involved in the differentiation of monocytes and enterocytes.cite web | title = Entrez Gene: UBE2V2 ubiquitin-conjugating enzyme E2 variant 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7336| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Fritsche J, Rehli M, Krause SW, "et al." |title=Molecular cloning of a 1alpha,25-dihydroxyvitamin D3-inducible transcript (DDVit 1) in human blood monocytes. |journal=Biochem. Biophys. Res. Commun. |volume=235 |issue= 2 |pages= 407–12 |year= 1997 |pmid= 9199207 |doi=
*cite journal | author=Sancho E, Vilá MR, Sánchez-Pulido L, "et al." |title=Role of UEV-1, an inactive variant of the E2 ubiquitin-conjugating enzymes, in in vitro differentiation and cell cycle behavior of HT-29-M6 intestinal mucosecretory cells. |journal=Mol. Cell. Biol. |volume=18 |issue= 1 |pages= 576–89 |year= 1998 |pmid= 9418904 |doi=
*cite journal | author=Xiao W, Lin SL, Broomfield S, "et al." |title=The products of the yeast MMS2 and two human homologs (hMMS2 and CROC-1) define a structurally and functionally conserved Ubc-like protein family. |journal=Nucleic Acids Res. |volume=26 |issue= 17 |pages= 3908–14 |year= 1998 |pmid= 9705497 |doi=
*cite journal | author=Hofmann RM, Pickart CM |title=Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair. |journal=Cell |volume=96 |issue= 5 |pages= 645–53 |year= 1999 |pmid= 10089880 |doi=
*cite journal | author=Chan NL, Hill CP |title=Defining polyubiquitin chain topology. |journal=Nat. Struct. Biol. |volume=8 |issue= 8 |pages= 650–2 |year= 2001 |pmid= 11473244 |doi= 10.1038/90337
*cite journal | author=Moraes TF, Edwards RA, McKenna S, "et al." |title=Crystal structure of the human ubiquitin conjugating enzyme complex, hMms2-hUbc13. |journal=Nat. Struct. Biol. |volume=8 |issue= 8 |pages= 669–73 |year= 2001 |pmid= 11473255 |doi= 10.1038/90373
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gevaert K, Goethals M, Martens L, "et al." |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810
*cite journal | author=Bothos J, Summers MK, Venere M, "et al." |title=The Chfr mitotic checkpoint protein functions with Ubc13-Mms2 to form Lys63-linked polyubiquitin chains. |journal=Oncogene |volume=22 |issue= 46 |pages= 7101–7 |year= 2003 |pmid= 14562038 |doi= 10.1038/sj.onc.1206831
*cite journal | author=Zhou H, Wertz I, O'Rourke K, "et al." |title=Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO. |journal=Nature |volume=427 |issue= 6970 |pages= 167–71 |year= 2004 |pmid= 14695475 |doi= 10.1038/nature02273
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Simpson LJ, Sale JE |title=UBE2V2 (MMS2) is not required for effective immunoglobulin gene conversion or DNA damage tolerance in DT40. |journal=DNA Repair (Amst.) |volume=4 |issue= 4 |pages= 503–10 |year= 2005 |pmid= 15725630 |doi= 10.1016/j.dnarep.2004.12.002
*cite journal | author=Pastushok L, Moraes TF, Ellison MJ, Xiao W |title=A single Mms2 "key" residue insertion into a Ubc13 pocket determines the interface specificity of a human Lys63 ubiquitin conjugation complex. |journal=J. Biol. Chem. |volume=280 |issue= 18 |pages= 17891–900 |year= 2005 |pmid= 15749714 |doi= 10.1074/jbc.M410469200
*cite journal | author=Spyracopoulos L, Lewis MJ, Saltibus LF |title=Main chain and side chain dynamics of the ubiquitin conjugating enzyme variant human Mms2 in the free and ubiquitin-bound States. |journal=Biochemistry |volume=44 |issue= 24 |pages= 8770–81 |year= 2005 |pmid= 15952783 |doi= 10.1021/bi050065k
*cite journal | author=Andersen PL, Zhou H, Pastushok L, "et al." |title=Distinct regulation of Ubc13 functions by the two ubiquitin-conjugating enzyme variants Mms2 and Uev1A. |journal=J. Cell Biol. |volume=170 |issue= 5 |pages= 745–55 |year= 2005 |pmid= 16129784 |doi= 10.1083/jcb.200502113
*cite journal | author=Stelzl U, Worm U, Lalowski M, "et al." |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029
*cite journal | author=Wen R, Newton L, Li G, "et al." |title=Arabidopsis thaliana UBC13: implication of error-free DNA damage tolerance and Lys63-linked polyubiquitylation in plants. |journal=Plant Mol. Biol. |volume=61 |issue= 1-2 |pages= 241–53 |year= 2006 |pmid= 16786304 |doi= 10.1007/s11103-006-0007-x
*cite journal | author=Zhao GY, Sonoda E, Barber LJ, "et al." |title=A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination. |journal=Mol. Cell |volume=25 |issue= 5 |pages= 663–75 |year= 2007 |pmid= 17349954 |doi= 10.1016/j.molcel.2007.01.029

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