UBR1

Ubiquitin protein ligase E3 component n-recognin 1, also known as UBR1, is a human gene.cite web | title = Entrez Gene: UBR1 ubiquitin protein ligase E3 component n-recognin 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=197131| accessdate = ]

PBB_Summary
section_title =
summary_text = The N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway, encoded by this gene, binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein. The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome.cite web | title = Entrez Gene: UBR1 ubiquitin protein ligase E3 component n-recognin 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=197131| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Varshavsky A |title=The N-end rule: functions, mysteries, uses. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 22 |pages= 12142–9 |year= 1996 |pmid= 8901547 |doi=
*cite journal | author=Chiannilkulchai N, Pasturaud P, Richard I, "et al." |title=A primary expression map of the chromosome 15q15 region containing the recessive form of limb-girdle muscular dystrophy (LGMD2A) gene. |journal=Hum. Mol. Genet. |volume=4 |issue= 4 |pages= 717–25 |year= 1995 |pmid= 7633422 |doi=
*cite journal | author=Kwon YT, Reiss Y, Fried VA, "et al." |title=The mouse and human genes encoding the recognition component of the N-end rule pathway. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 14 |pages= 7898–903 |year= 1998 |pmid= 9653112 |doi=
*cite journal | author=Dgany O, Avidan N, Delaunay J, "et al." |title=Congenital dyserythropoietic anemia type I is caused by mutations in codanin-1. |journal=Am. J. Hum. Genet. |volume=71 |issue= 6 |pages= 1467–74 |year= 2003 |pmid= 12434312 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101
*cite journal | author=Yin J, Kwon YT, Varshavsky A, Wang W |title=RECQL4, mutated in the Rothmund-Thomson and RAPADILINO syndromes, interacts with ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway. |journal=Hum. Mol. Genet. |volume=13 |issue= 20 |pages= 2421–30 |year= 2005 |pmid= 15317757 |doi= 10.1093/hmg/ddh269
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Kwak KS, Zhou X, Solomon V, "et al." |title=Regulation of protein catabolism by muscle-specific and cytokine-inducible ubiquitin ligase E3alpha-II during cancer cachexia. |journal=Cancer Res. |volume=64 |issue= 22 |pages= 8193–8 |year= 2005 |pmid= 15548684 |doi= 10.1158/0008-5472.CAN-04-2102
*cite journal | author=Tasaki T, Mulder LC, Iwamatsu A, "et al." |title=A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons. |journal=Mol. Cell. Biol. |volume=25 |issue= 16 |pages= 7120–36 |year= 2005 |pmid= 16055722 |doi= 10.1128/MCB.25.16.7120-7136.2005
*cite journal | author=Stelzl U, Worm U, Lalowski M, "et al." |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029
*cite journal | author=Zenker M, Mayerle J, Lerch MM, "et al." |title=Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome). |journal=Nat. Genet. |volume=37 |issue= 12 |pages= 1345–50 |year= 2006 |pmid= 16311597 |doi= 10.1038/ng1681
*cite journal | author=Sasaki T, Kojima H, Kishimoto R, "et al." |title=Spatiotemporal regulation of c-Fos by ERK5 and the E3 ubiquitin ligase UBR1, and its biological role. |journal=Mol. Cell |volume=24 |issue= 1 |pages= 63–75 |year= 2006 |pmid= 17018293 |doi= 10.1016/j.molcel.2006.08.005
*cite journal | author=Zou W, Wang J, Zhang DE |title=Negative regulation of ISG15 E3 ligase EFP through its autoISGylation. |journal=Biochem. Biophys. Res. Commun. |volume=354 |issue= 1 |pages= 321–7 |year= 2007 |pmid= 17222803 |doi= 10.1016/j.bbrc.2006.12.210
*cite journal | author=Sakane A, Hatakeyama S, Sasaki T |title=Involvement of Rabring7 in EGF receptor degradation as an E3 ligase. |journal=Biochem. Biophys. Res. Commun. |volume=357 |issue= 4 |pages= 1058–64 |year= 2007 |pmid= 17462600 |doi= 10.1016/j.bbrc.2007.04.052
*cite journal | author=Wei S, Lin LF, Yang CC, "et al." |title=Thiazolidinediones modulate the expression of beta-catenin and other cell-cycle regulatory proteins by targeting the F-box proteins of Skp1-Cul1-F-box protein E3 ubiquitin ligase independently of peroxisome proliferator-activated receptor gamma. |journal=Mol. Pharmacol. |volume=72 |issue= 3 |pages= 725–33 |year= 2007 |pmid= 17569795 |doi= 10.1124/mol.107.035287

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