DAB2IP

DAB2 interacting protein
Identifiers
Symbols	DAB2IP; AF9Q34; AIP1; DIP1/2; FLJ39072; KIAA1743
External IDs	OMIM: 609205 MGI: 1916851 HomoloGene: 13058 GeneCards: DAB2IP Gene
Gene Ontology Molecular function • Ras GTPase activator activity • Ras GTPase activator activity • death receptor binding • protein kinase binding • mitogen-activated protein kinase kinase kinase binding • signaling adaptor activity • protein homodimerization activity • protein phosphatase 2A binding • 14-3-3 protein binding Cellular component • intracellular • cytoplasm • plasma membrane • intrinsic to internal side of plasma membrane Biological process • negative regulation of transcription from RNA polymerase II promoter • negative regulation of transcription from RNA polymerase II promoter • activation of JUN kinase activity • positive regulation of signal transduction • negative regulation of epithelial cell migration • negative regulation of epithelial to mesenchymal transition • negative regulation of NF-kappaB transcription factor activity • positive regulation of Ras GTPase activity • positive regulation of Ras GTPase activity • negative regulation of Ras GTPase activity • negative regulation of catenin import into nucleus • negative regulation of epidermal growth factor receptor signaling pathway • positive regulation of apoptosis • negative regulation of I-kappaB kinase/NF-kappaB cascade • negative regulation of MAP kinase activity • negative regulation of MAP kinase activity • positive regulation of JUN kinase activity • positive regulation of transcription from RNA polymerase II promoter • negative regulation of Ras protein signal transduction • negative regulation of Ras protein signal transduction • negative regulation of fibroblast proliferation • negative regulation of epithelial cell proliferation • regulation of small GTPase mediated signal transduction • apoptosis in response to endoplasmic reticulum stress • cellular response to tumor necrosis factor • cellular response to epidermal growth factor stimulus • negative regulation of protein serine/threonine kinase activity • positive regulation of protein serine/threonine kinase activity • negative regulation of canonical Wnt receptor signaling pathway Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	153090	69601
Ensembl	ENSG00000136848	ENSMUSG00000026883
UniProt	Q5VWQ8	Q3UHC7
RefSeq (mRNA)	NM_032552.2	NM_001001602
RefSeq (protein)	NP_115941.2	NP_001001602
Location (UCSC)	Chr 9: 124.33 – 124.55 Mb	Chr 2: 35.41 – 35.59 Mb
PubMed search	[1]	[2]

Disabled homolog 2-interacting protein is a protein that in humans is encoded by the DAB2IP gene.^[1][2][3]

DAB2IP is a Ras (MIM 190020) GTPase-activating protein (GAP) that acts as a tumor suppressor gene and is inactivated by methylation in prostate and breast cancers (Yano et al., 2005).[supplied by OMIM]^[3]

Interactions

DAB2IP has been shown to interact with DAB2.^[2]

References

1. ^ Chen H, Pong RC, Wang Z, Hsieh JT (Apr 2002). "Differential regulation of the human gene DAB2IP in normal and malignant prostatic epithelia: cloning and characterization". Genomics 79 (4): 573–81. doi:10.1006/geno.2002.6739. PMID 11944990. 
2. ^ ^{a b} Wang Z, Tseng CP, Pong RC, Chen H, McConnell JD, Navone N, Hsieh JT (Apr 2002). "The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate cancer. Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2". J Biol Chem 277 (15): 12622–31. doi:10.1074/jbc.M110568200. PMID 11812785. 
3. ^ ^{a b} "Entrez Gene: DAB2IP DAB2 interacting protein". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=153090. 

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954. 
• Nagase T, Kikuno R, Hattori A, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970. 
• Chen H, Toyooka S, Gazdar AF, Hsieh JT (2003). "Epigenetic regulation of a novel tumor suppressor gene (hDAB2IP) in prostate cancer cell lines". J. Biol. Chem. 278 (5): 3121–30. doi:10.1074/jbc.M208230200. PMID 12446720. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Zhang R, He X, Liu W, et al. (2003). "AIP1 mediates TNF-α–induced ASK1 activation by facilitating dissociation of ASK1 from its inhibitor 14-3-3". J. Clin. Invest. 111 (12): 1933–43. doi:10.1172/JCI17790. PMC 161425. PMID 12813029. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=161425. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• von Bergh AR, Wijers PM, Groot AJ, et al. (2004). "Identification of a novel RAS GTPase-activating protein (RASGAP) gene at 9q34 as an MLL fusion partner in a patient with de novo acute myeloid leukemia". Genes Chromosomes Cancer 39 (4): 324–34. doi:10.1002/gcc.20004. PMID 14978793. 
• Dote H, Toyooka S, Tsukuda K, et al. (2004). "Aberrant promoter methylation in human DAB2 interactive protein (hDAB2IP) gene in breast cancer". Clin. Cancer Res. 10 (6): 2082–9. doi:10.1158/1078-0432.CCR-03-0236. PMID 15041729. 
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2734081. 
• Zhang H, Zhang R, Luo Y, et al. (2004). "AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation". J. Biol. Chem. 279 (43): 44955–65. doi:10.1074/jbc.M407617200. PMID 15310755. 
• Yano M, Toyooka S, Tsukuda K, et al. (2004). "Aberrant promoter methylation of human DAB2 interactive protein (hDAB2IP) gene in lung cancers". Int. J. Cancer 113 (1): 59–66. doi:10.1002/ijc.20531. PMID 15386433. 
• Chen H, Tu SW, Hsieh JT (2005). "Down-regulation of human DAB2IP gene expression mediated by polycomb Ezh2 complex and histone deacetylase in prostate cancer". J. Biol. Chem. 280 (23): 22437–44. doi:10.1074/jbc.M501379200. PMID 15817459. 
• Kunze E, Von Bonin F, Werner C, et al. (2006). "Transitional cell carcinomas and nonurothelial carcinomas of the urinary bladder differ in the promoter methylation status of the caveolin-1, hDAB2IP and p53 genes, but not in the global methylation of Alu elements". Int. J. Mol. Med. 17 (1): 3–13. PMID 16328005. 
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.