UBE2D1

Ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast), also known as UBE2D1, is a human gene.cite web | title = Entrez Gene: UBE2D1 ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7321| accessdate = ]

PBB_Summary
section_title =
summary_text = The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases.cite web | title = Entrez Gene: UBE2D1 ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7321| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Scheffner M, Huibregtse JM, Howley PM |title=Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 19 |pages= 8797–801 |year= 1994 |pmid= 8090726 |doi=
*cite journal | author=Jensen JP, Bates PW, Yang M, "et al." |title=Identification of a family of closely related human ubiquitin conjugating enzymes. |journal=J. Biol. Chem. |volume=270 |issue= 51 |pages= 30408–14 |year= 1996 |pmid= 8530467 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Hatakeyama S, Jensen JP, Weissman AM |title=Subcellular localization and ubiquitin-conjugating enzyme (E2) interactions of mammalian HECT family ubiquitin protein ligases. |journal=J. Biol. Chem. |volume=272 |issue= 24 |pages= 15085–92 |year= 1997 |pmid= 9182527 |doi=
*cite journal | author=Gutierrez JA, Yu J, Rivera S, Wessling-Resnick M |title=Functional expression cloning and characterization of SFT, a stimulator of Fe transport. |journal=J. Cell Biol. |volume=139 |issue= 4 |pages= 895–905 |year= 1997 |pmid= 9362508 |doi=
*cite journal | author=Gutierrez JA, Yu J, Wessling-Resnick M |title=Characterization and chromosomal mapping of the human gene for SFT, a stimulator of Fe transport. |journal=Biochem. Biophys. Res. Commun. |volume=253 |issue= 3 |pages= 739–42 |year= 1999 |pmid= 9918797 |doi= 10.1006/bbrc.1998.9836
*cite journal | author=Nuber U, Scheffner M |title=Identification of determinants in E2 ubiquitin-conjugating enzymes required for hect E3 ubiquitin-protein ligase interaction. |journal=J. Biol. Chem. |volume=274 |issue= 11 |pages= 7576–82 |year= 1999 |pmid= 10066826 |doi=
*cite journal | author=Robinson PA, Leek JP, Ardley HC, "et al." |title=Assignment of UBE2D1 to human chromosome bands 10q11.2-->q21 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=83 |issue= 3-4 |pages= 247–8 |year= 1999 |pmid= 10072594 |doi=
*cite journal | author=Kamura T, Sato S, Iwai K, "et al." |title=Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 19 |pages= 10430–5 |year= 2000 |pmid= 10973499 |doi= 10.1073/pnas.190332597
*cite journal | author=Pringa E, Martinez-Noel G, Muller U, Harbers K |title=Interaction of the ring finger-related U-box motif of a nuclear dot protein with ubiquitin-conjugating enzymes. |journal=J. Biol. Chem. |volume=276 |issue= 22 |pages= 19617–23 |year= 2001 |pmid= 11274149 |doi= 10.1074/jbc.M100192200
*cite journal | author=Hashizume R, Fukuda M, Maeda I, "et al." |title=The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation. |journal=J. Biol. Chem. |volume=276 |issue= 18 |pages= 14537–40 |year= 2001 |pmid= 11278247 |doi= 10.1074/jbc.C000881200
*cite journal | author=Matsuzawa SI, Reed JC |title=Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses. |journal=Mol. Cell |volume=7 |issue= 5 |pages= 915–26 |year= 2001 |pmid= 11389839 |doi=
*cite journal | author=Jiang J, Ballinger CA, Wu Y, "et al." |title=CHIP is a U-box-dependent E3 ubiquitin ligase: identification of Hsc70 as a target for ubiquitylation. |journal=J. Biol. Chem. |volume=276 |issue= 46 |pages= 42938–44 |year= 2001 |pmid= 11557750 |doi= 10.1074/jbc.M101968200
*cite journal | author=Chen A, Kleiman FE, Manley JL, "et al." |title=Autoubiquitination of the BRCA1*BARD1 RING ubiquitin ligase. |journal=J. Biol. Chem. |volume=277 |issue= 24 |pages= 22085–92 |year= 2002 |pmid= 11927591 |doi= 10.1074/jbc.M201252200
*cite journal | author=Badciong JC, Haas AL |title=MdmX is a RING finger ubiquitin ligase capable of synergistically enhancing Mdm2 ubiquitination. |journal=J. Biol. Chem. |volume=277 |issue= 51 |pages= 49668–75 |year= 2003 |pmid= 12393902 |doi= 10.1074/jbc.M208593200
*cite journal | author=Kentsis A, Gordon RE, Borden KL |title=Control of biochemical reactions through supramolecular RING domain self-assembly. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 24 |pages= 15404–9 |year= 2003 |pmid= 12438698 |doi= 10.1073/pnas.202608799
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gehrke SG, Riedel HD, Herrmann T, "et al." |title=UbcH5A, a member of human E2 ubiquitin-conjugating enzymes, is closely related to SFT, a stimulator of iron transport, and is up-regulated in hereditary hemochromatosis. |journal=Blood |volume=101 |issue= 8 |pages= 3288–93 |year= 2003 |pmid= 12480712 |doi= 10.1182/blood-2002-07-2192
*cite journal | author=Mallery DL, Vandenberg CJ, Hiom K |title=Activation of the E3 ligase function of the BRCA1/BARD1 complex by polyubiquitin chains. |journal=EMBO J. |volume=21 |issue= 24 |pages= 6755–62 |year= 2004 |pmid= 12485996 |doi=
*cite journal | author=Takeyama K, Aguiar RC, Gu L, "et al." |title=The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity. |journal=J. Biol. Chem. |volume=278 |issue= 24 |pages= 21930–7 |year= 2003 |pmid= 12670957 |doi= 10.1074/jbc.M301157200

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