UBE2G2

Ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast), also known as UBE2G2, is a human gene.cite web | title = Entrez Gene: UBE2G2 ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7327| accessdate = ]

PBB_Summary
section_title =
summary_text = The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse counterpart. This gene is ubiquitously expressed, with high expression seen in adult muscle. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.cite web | title = Entrez Gene: UBE2G2 ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7327| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Chen P, Johnson P, Sommer T, "et al." |title=Multiple ubiquitin-conjugating enzymes participate in the in vivo degradation of the yeast MAT alpha 2 repressor. |journal=Cell |volume=74 |issue= 2 |pages= 357–69 |year= 1993 |pmid= 8393731 |doi=
*cite journal | author=Katsanis N, Fisher EM |title=Identification, expression, and chromosomal localization of ubiquitin conjugating enzyme 7 (UBE2G2), a human homologue of the Saccharomyces cerevisiae ubc7 gene. |journal=Genomics |volume=51 |issue= 1 |pages= 128–31 |year= 1998 |pmid= 9693041 |doi= 10.1006/geno.1998.5263
*cite journal | author=Rose SA, Leek JP, Moynihan TP, "et al." |title=Assignment1 of the ubiquitin conjugating enzyme gene, UBE2G2, to human chromosome band 21q22.3 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=83 |issue= 1-2 |pages= 98–9 |year= 1999 |pmid= 9925943 |doi=
*cite journal | author=Moynihan TP, Ardley HC, Nuber U, "et al." |title=The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1. |journal=J. Biol. Chem. |volume=274 |issue= 43 |pages= 30963–8 |year= 1999 |pmid= 10521492 |doi=
*cite journal | author=Huang L, Kinnucan E, Wang G, "et al." |title=Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade. |journal=Science |volume=286 |issue= 5443 |pages= 1321–6 |year= 1999 |pmid= 10558980 |doi=
*cite journal | author=Hattori M, Fujiyama A, Taylor TD, "et al." |title=The DNA sequence of human chromosome 21. |journal=Nature |volume=405 |issue= 6784 |pages= 311–9 |year= 2000 |pmid= 10830953 |doi= 10.1038/35012518
*cite journal | author=Lenk U, Sommer T |title=Ubiquitin-mediated proteolysis of a short-lived regulatory protein depends on its cellular localization. |journal=J. Biol. Chem. |volume=275 |issue= 50 |pages= 39403–10 |year= 2001 |pmid= 10991948 |doi= 10.1074/jbc.M006949200
*cite journal | author=Joazeiro CA, Hunter T |title=Biochemistry. Ubiquitination--more than two to tango. |journal=Science |volume=289 |issue= 5487 |pages= 2061–2 |year= 2000 |pmid= 11032556 |doi=
*cite journal | author=Tiwari S, Weissman AM |title=Endoplasmic reticulum (ER)-associated degradation of T cell receptor subunits. Involvement of ER-associated ubiquitin-conjugating enzymes (E2s). |journal=J. Biol. Chem. |volume=276 |issue= 19 |pages= 16193–200 |year= 2001 |pmid= 11278356 |doi= 10.1074/jbc.M007640200
*cite journal | author=Fang S, Ferrone M, Yang C, "et al." |title=The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 25 |pages= 14422–7 |year= 2002 |pmid= 11724934 |doi= 10.1073/pnas.251401598
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Webster JM, Tiwari S, Weissman AM, Wojcikiewicz RJ |title=Inositol 1,4,5-trisphosphate receptor ubiquitination is mediated by mammalian Ubc7, a component of the endoplasmic reticulum-associated degradation pathway, and is inhibited by chelation of intracellular Zn2+. |journal=J. Biol. Chem. |volume=278 |issue= 40 |pages= 38238–46 |year= 2003 |pmid= 12869571 |doi= 10.1074/jbc.M305600200
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Chen B, Mariano J, Tsai YC, "et al." |title=The activity of a human endoplasmic reticulum-associated degradation E3, gp78, requires its Cue domain, RING finger, and an E2-binding site. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 2 |pages= 341–6 |year= 2006 |pmid= 16407162 |doi= 10.1073/pnas.0506618103
*cite journal | author=Arai R, Yoshikawa S, Murayama K, "et al." |title=Structure of human ubiquitin-conjugating enzyme E2 G2 (UBE2G2/UBC7). |journal=Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. |volume=62 |issue= Pt 4 |pages= 330–4 |year= 2006 |pmid= 16582478 |doi= 10.1107/S1744309106009006
*cite journal | author=Hu YH, Warnatz HJ, Vanhecke D, "et al." |title=Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. |journal=BMC Genomics |volume=7 |issue= |pages= 155 |year= 2006 |pmid= 16780588 |doi= 10.1186/1471-2164-7-155
*cite journal | author=Ewing RM, Chu P, Elisma F, "et al." |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134

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