UBE2N

Ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast), also known as UBE2N, is a human gene.cite web | title = Entrez Gene: UBE2N ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7334| accessdate = ]

PBB_Summary
section_title =
summary_text = The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Studies in mouse suggest that this protein plays a role in DNA postreplication repair.cite web | title = Entrez Gene: UBE2N ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7334| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Yamaguchi T, Kim NS, Sekine S, "et al." |title=Cloning and expression of cDNA encoding a human ubiquitin-conjugating enzyme similar to the Drosophila bendless gene product. |journal=J. Biochem. |volume=120 |issue= 3 |pages= 494–97 |year= 1997 |pmid= 8902611 |doi=
*cite journal | author=Hofmann RM, Pickart CM |title=Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair. |journal=Cell |volume=96 |issue= 5 |pages= 645–53 |year= 1999 |pmid= 10089880 |doi=
*cite journal | author=Deng L, Wang C, Spencer E, "et al." |title=Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. |journal=Cell |volume=103 |issue= 2 |pages= 351–61 |year= 2000 |pmid= 11057907 |doi=
*cite journal | author=Chan NL, Hill CP |title=Defining polyubiquitin chain topology. |journal=Nat. Struct. Biol. |volume=8 |issue= 8 |pages= 650–2 |year= 2001 |pmid= 11473244 |doi= 10.1038/90337
*cite journal | author=Moraes TF, Edwards RA, McKenna S, "et al." |title=Crystal structure of the human ubiquitin conjugating enzyme complex, hMms2-hUbc13. |journal=Nat. Struct. Biol. |volume=8 |issue= 8 |pages= 669–73 |year= 2001 |pmid= 11473255 |doi= 10.1038/90373
*cite journal | author=Ashley C, Pastushok L, McKenna S, "et al." |title=Roles of mouse UBC13 in DNA postreplication repair and Lys63-linked ubiquitination. |journal=Gene |volume=285 |issue= 1-2 |pages= 183–91 |year= 2002 |pmid= 12039045 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=McKenna S, Moraes T, Pastushok L, "et al." |title=An NMR-based model of the ubiquitin-bound human ubiquitin conjugation complex Mms2.Ubc13. The structural basis for lysine 63 chain catalysis. |journal=J. Biol. Chem. |volume=278 |issue= 15 |pages= 13151–8 |year= 2003 |pmid= 12569095 |doi= 10.1074/jbc.M212353200
*cite journal | author=Anandasabapathy N, Ford GS, Bloom D, "et al." |title=GRAIL: an E3 ubiquitin ligase that inhibits cytokine gene transcription is expressed in anergic CD4+ T cells. |journal=Immunity |volume=18 |issue= 4 |pages= 535–47 |year= 2003 |pmid= 12705856 |doi=
*cite journal | author=Ewart-Toland A, Briassouli P, de Koning JP, "et al." |title=Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human. |journal=Nat. Genet. |volume=34 |issue= 4 |pages= 403–12 |year= 2003 |pmid= 12881723 |doi= 10.1038/ng1220
*cite journal | author=Bothos J, Summers MK, Venere M, "et al." |title=The Chfr mitotic checkpoint protein functions with Ubc13-Mms2 to form Lys63-linked polyubiquitin chains. |journal=Oncogene |volume=22 |issue= 46 |pages= 7101–7 |year= 2003 |pmid= 14562038 |doi= 10.1038/sj.onc.1206831
*cite journal | author=Zhou H, Wertz I, O'Rourke K, "et al." |title=Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO. |journal=Nature |volume=427 |issue= 6970 |pages= 167–71 |year= 2004 |pmid= 14695475 |doi= 10.1038/nature02273
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Sun L, Deng L, Ea CK, "et al." |title=The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes. |journal=Mol. Cell |volume=14 |issue= 3 |pages= 289–301 |year= 2004 |pmid= 15125833 |doi=
*cite journal | author=Colland F, Jacq X, Trouplin V, "et al." |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Pastushok L, Moraes TF, Ellison MJ, Xiao W |title=A single Mms2 "key" residue insertion into a Ubc13 pocket determines the interface specificity of a human Lys63 ubiquitin conjugation complex. |journal=J. Biol. Chem. |volume=280 |issue= 18 |pages= 17891–900 |year= 2005 |pmid= 15749714 |doi= 10.1074/jbc.M410469200
*cite journal | author=Takeuchi T, Yokosawa H |title=ISG15 modification of Ubc13 suppresses its ubiquitin-conjugating activity. |journal=Biochem. Biophys. Res. Commun. |volume=336 |issue= 1 |pages= 9–13 |year= 2005 |pmid= 16112642 |doi= 10.1016/j.bbrc.2005.08.034
*cite journal | author=Zou W, Papov V, Malakhova O, "et al." |title=ISG15 modification of ubiquitin E2 Ubc13 disrupts its ability to form thioester bond with ubiquitin. |journal=Biochem. Biophys. Res. Commun. |volume=336 |issue= 1 |pages= 61–8 |year= 2005 |pmid= 16122702 |doi= 10.1016/j.bbrc.2005.08.038

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