Orosomucoid

orosomucoid 1
Identifiers
Symbol	ORM1
Entrez	5004
HUGO	8498
OMIM	138600
RefSeq	NM_000607
UniProt	P02763
Other data
Locus	Chr. 9 q31-qter

orosomucoid 2
Identifiers
Symbol	ORM2
Entrez	5005
HUGO	8499
OMIM	138610
RefSeq	NM_000608
UniProt	P19652
Other data
Locus	Chr. 9 q31-qter

Orosomucoid (ORM) or alpha-1-acid glycoprotein (AGP or AAG) is an acute phase (acute phase protein) plasma alpha-globulin glycoprotein and is modulated by two polymorphic genes. It is synthesized primarily in hepatocytes and has a normal plasma concentration between 0.6-1.2 mg/mL (1-3% plasma protein).^[1] Plasma levels are affected by pregnancy, certain drugs, and certain diseases, particularly HIV.^[1]

The only established function of ORM is to act as a carrier of basic and neutrally charged lipophilic compounds. In medicine, it is known as the primary carrier of basic drugs (whereas albumin carries acidic drugs), steroids, and protease inhibitors.^[1][2]

Orosomucoid increases in amount in obstructive jaundices while diminishes in hepatocellular jaundice and in intestinal infections.

References

1. ^ ^{a b c} Colombo S, Buclin T, Décosterd LA, Telenti A, Furrer H, Lee BL, Biollaz J, Eap CB (2006). "Orosomucoid (alpha1-acid glycoprotein) plasma concentration and genetic variants: effects on human immunodeficiency virus protease inhibitor clearance and cellular accumulation". Clin. Pharmacol. Ther. 80 (4): 307–18. doi:10.1016/j.clpt.2006.06.006. PMID 17015049. 
2. ^ Urien S, Brée F, Testa B, Tillement JP (1991). "pH-dependency of basic ligand binding to alpha 1-acid glycoprotein (orosomucoid)". Biochem. J. 280 ( Pt 1): 277–80. PMC 1130632. PMID 1741754. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1130632. 

External links

• MeSH Orosomucoid