- Orosomucoid
-
orosomucoid 1 Identifiers Symbol ORM1 Entrez 5004 HUGO 8498 OMIM 138600 RefSeq NM_000607 UniProt P02763 Other data Locus Chr. 9 q31-qter orosomucoid 2 Identifiers Symbol ORM2 Entrez 5005 HUGO 8499 OMIM 138610 RefSeq NM_000608 UniProt P19652 Other data Locus Chr. 9 q31-qter Orosomucoid (ORM) or alpha-1-acid glycoprotein (AGP or AAG) is an acute phase (acute phase protein) plasma alpha-globulin glycoprotein and is modulated by two polymorphic genes. It is synthesized primarily in hepatocytes and has a normal plasma concentration between 0.6-1.2 mg/mL (1-3% plasma protein).[1] Plasma levels are affected by pregnancy, certain drugs, and certain diseases, particularly HIV.[1]
The only established function of ORM is to act as a carrier of basic and neutrally charged lipophilic compounds. In medicine, it is known as the primary carrier of basic drugs (whereas albumin carries acidic drugs), steroids, and protease inhibitors.[1][2]
Orosomucoid increases in amount in obstructive jaundices while diminishes in hepatocellular jaundice and in intestinal infections.
References
- ^ a b c Colombo S, Buclin T, Décosterd LA, Telenti A, Furrer H, Lee BL, Biollaz J, Eap CB (2006). "Orosomucoid (alpha1-acid glycoprotein) plasma concentration and genetic variants: effects on human immunodeficiency virus protease inhibitor clearance and cellular accumulation". Clin. Pharmacol. Ther. 80 (4): 307–18. doi:10.1016/j.clpt.2006.06.006. PMID 17015049.
- ^ Urien S, Brée F, Testa B, Tillement JP (1991). "pH-dependency of basic ligand binding to alpha 1-acid glycoprotein (orosomucoid)". Biochem. J. 280 ( Pt 1): 277–80. PMC 1130632. PMID 1741754. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1130632.
External links
Proteins: Globular proteins Serum globulins serpins: alpha-1 (Alpha 1-antichymotrypsin, Alpha 1-antitrypsin) · alpha-2 (Alpha 2-antiplasmin) · Antithrombin (Heparin cofactor II)
carrier proteins: alpha-1 (Transcortin) · alpha-2 (Ceruloplasmin) · Retinol binding protein
other: alpha-1 (Orosomucoid) · alpha-2 (alpha-2-Macroglobulin, Haptoglobin)carrier proteins: Sex hormone-binding globulin · Transferrin
other: Angiostatin · Hemopexin · Beta-2 microglobulin · Factor H · Plasminogen · ProperdinOtherOther globulins Albumins Othersee also disorders of globin and globulin proteins
B proteins: BY STRUCTURE: membrane, globular (en, ca, an), fibrousMucoproteins OtherProteoglycan Chondroitin sulfate proteoglycans: Aggrecan · Neurocan · Brevican · CD44 · CSPG4 · CSPG5 · Platelet factor 4 · Structural maintenance of chromosomes 3Fibromodulin · Lumican · KeratocanOther Activin and inhibin · ADAM · Alpha 1-antichymotrypsin · Apolipoprotein H · CD70 · Asialoglycoprotein · Avidin · B-cell activating factor · 4-1BB ligand · Cholesterylester transfer protein · Clusterin · Colony-stimulating factor · Hemopexin · Lactoferrin · Membrane glycoproteins · Myelin protein zero · Osteonectin · Protein C · Protein S · Serum amyloid P component · Sialoglycoprotein (CD43, Glycophorin, Glycophorin C) · Thrombopoietin · Thyroglobulin · Thyroxine-binding proteins · Transcortin · Tumor necrosis factor-alpha · Uteroglobin · Vitronectinbiochemical families: prot · nucl · carb (glpr, alco, glys) · lipd (fata/i, phld, strd, gllp, eico) · amac/i · ncbs/i · ttpy/iAmyloid Other positive Alpha 1-antichymotrypsin - Alpha 1-antitrypsin - Alpha 2-macroglobulin - C-reactive protein - Ceruloplasmin - C3 - Ferritin - Fibrin - Haptoglobin - Hemopexin - OrosomucoidNegative Categories:- Genes on chromosome 9
- Acute phase proteins
- Glycoproteins
- Molecular biology
- Proteomics
- Chromosome 9 gene stubs
Wikimedia Foundation. 2010.