MUC4

Mucin 4, cell surface associated
Identifiers
Symbols	MUC4; ASGP; HSA276359; MUC-4
External IDs	OMIM: 158372 MGI: 2153525 HomoloGene: 124469 GeneCards: MUC4 Gene
Gene Ontology Molecular function • ErbB-2 class receptor binding • extracellular matrix structural constituent • extracellular matrix constituent, lubricant activity Cellular component • extracellular region • proteinaceous extracellular matrix • plasma membrane • integral to plasma membrane • membrane Biological process • cell adhesion • cell-matrix adhesion • biological_process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4585	140474
Ensembl	ENSG00000145113	ENSMUSG00000079620
UniProt	Q99102	n/a
RefSeq (mRNA)	NM_004532.5	NM_080457.3
RefSeq (protein)	NP_004523.3	NP_536705.3
Location (UCSC)	Chr 3: 195.47 – 195.54 Mb	Chr 16: 32.74 – 32.78 Mb
PubMed search	[1]	[2]

Mucin-4 is a protein that in humans is encoded by the MUC4 gene.^[1]

The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. At least two dozen transcript variants of this gene have been found, although for many of them the full-length transcript has not been determined or they are found only in tumor tissues. This gene contains a region in the coding sequence that has a variable number (>100) of 48 nt tandem repeats, although only two repeats are included in these sequences.^[2]

References

1. ^ Porchet N, Nguyen VC, Dufosse J, Audie JP, Guyonnet-Duperat V, Gross MS, Denis C, Degand P, Bernheim A, Aubert JP (May 1991). "Molecular cloning and chromosomal localization of a novel human tracheo-bronchial mucin cDNA containing tandemly repeated sequences of 48 base pairs". Biochem Biophys Res Commun 175 (2): 414–22. doi:10.1016/0006-291X(91)91580-6. PMID 1673336. 
2. ^ "Entrez Gene: MUC4 mucin 4, cell surface associated". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4585. 

Further reading

• Carraway KL, Perez A, Idris N, et al. (2003). "Muc4/sialomucin complex, the intramembrane ErbB2 ligand, in cancer and epithelia: to protect and to survive.". Prog. Nucleic Acid Res. Mol. Biol. 71: 149–85. doi:10.1016/S0079-6603(02)71043-X. PMID 12102554. 
• Gross MS, Guyonnet-Duperat V, Porchet N, et al. (1992). "Mucin 4 (MUC4) gene: regional assignment (3q29) and RFLP analysis.". Ann. Genet. 35 (1): 21–6. PMID 1351710. 
• Audie JP, Tetaert D, Pigny P, et al. (1995). "Mucin gene expression in the human endocervix.". Hum. Reprod. 10 (1): 98–102. doi:10.1093/humrep/10.1.98. PMID 7745080. 
• Audie JP, Janin A, Porchet N, et al. (1994). "Expression of human mucin genes in respiratory, digestive, and reproductive tracts ascertained by in situ hybridization.". J. Histochem. Cytochem. 41 (10): 1479–85. PMID 8245407. 
• Nollet S, Moniaux N, Maury J, et al. (1998). "Human mucin gene MUC4: organization of its 5'-region and polymorphism of its central tandem repeat array.". Biochem. J.. 332 ( Pt 3): 739–48. PMC 1219535. PMID 9620877. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1219535. 
• Gipson IK, Spurr-Michaud S, Moccia R, et al. (1999). "MUC4 and MUC5B transcripts are the prevalent mucin messenger ribonucleic acids of the human endocervix.". Biol. Reprod. 60 (1): 58–64. doi:10.1095/biolreprod60.1.58. PMID 9858486. 
• Moniaux N, Nollet S, Porchet N, et al. (1999). "Complete sequence of the human mucin MUC4: a putative cell membrane-associated mucin.". Biochem. J.. 338 ( Pt 2) (2): 325–33. doi:10.1042/0264-6021:3380325. PMC 1220057. PMID 10024507. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1220057. 
• Moniaux N, Escande F, Batra SK, et al. (2000). "Alternative splicing generates a family of putative secreted and membrane-associated MUC4 mucins.". Eur. J. Biochem. 267 (14): 4536–44. doi:10.1046/j.1432-1327.2000.01504.x. PMID 10880978. 
• Choudhury A, Moniaux N, Winpenny JP, et al. (2000). "Human MUC4 mucin cDNA and its variants in pancreatic carcinoma.". J. Biochem. 128 (2): 233–43. PMID 10920259. 
• Idris N, Carothers Carraway CA, Carraway KL (2001). "Differential localization of ErbB2 in different tissues of the rat female reproductive tract: implications for the use of specific antibodies for ErbB2 analysis.". J. Cell. Physiol. 189 (2): 162–70. doi:10.1002/jcp.10012. PMID 11598901. 
• Arango ME, Li P, Komatsu M, et al. (2001). "Production and localization of Muc4/sialomucin complex and its receptor tyrosine kinase ErbB2 in the rat lacrimal gland.". Invest. Ophthalmol. Vis. Sci. 42 (12): 2749–56. PMID 11687512. 
• López-Ferrer A, Alameda F, Barranco C, et al. (2001). "MUC4 expression is increased in dysplastic cervical disorders.". Hum. Pathol. 32 (11): 1197–202. doi:10.1053/hupa.2001.28938. PMID 11727258. 
• Schwientek T, Bennett EP, Flores C, et al. (2002). "Functional conservation of subfamilies of putative UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferases in Drosophila, Caenorhabditis elegans, and mammals. One subfamily composed of l(2)35Aa is essential in Drosophila.". J. Biol. Chem. 277 (25): 22623–38. doi:10.1074/jbc.M202684200. PMID 11925450. 
• Desseyn JL, Clavereau I, Laine A (2002). "Cloning, chromosomal localization and characterization of the murine mucin gene orthologous to human MUC4.". Eur. J. Biochem. 269 (13): 3150–9. doi:10.1046/j.1432-1033.2002.02988.x. PMID 12084055. 
• Escande F, Lemaitre L, Moniaux N, et al. (2002). "Genomic organization of MUC4 mucin gene. Towards the characterization of splice variants.". Eur. J. Biochem. 269 (15): 3637–44. doi:10.1046/j.1432-1033.2002.03032.x. PMID 12153560. 
• Jepson S, Komatsu M, Haq B, et al. (2002). "Muc4/sialomucin complex, the intramembrane ErbB2 ligand, induces specific phosphorylation of ErbB2 and enhances expression of p27(kip), but does not activate mitogen-activated kinase or protein kinaseB/Akt pathways.". Oncogene 21 (49): 7524–32. doi:10.1038/sj.onc.1205970. PMID 12386815. 
• Swan JS, Arango ME, Carothers Carraway CA, Carraway KL (2002). "An ErbB2-Muc4 complex in rat ocular surface epithelia.". Curr. Eye Res. 24 (5): 397–402. doi:10.1076/ceyr.24.5.397.8521. PMID 12434309. 
• Fischer BM, Cuellar JG, Diehl ML, et al. (2003). "Neutrophil elastase increases MUC4 expression in normal human bronchial epithelial cells.". Am. J. Physiol. Lung Cell Mol. Physiol. 284 (4): L671–9. doi:10.1152/ajplung.00220.2002. PMID 12495942. 
• Chaturvedi P, Singh AP, Chakraborty S, Chauhan SC, Bafna S, Meza JL, Singh PK, Hollingsworth MA, Mehta PP, Batra SK. (2008). "MUC4 mucin interacts with and stabilizes the HER2 oncoprotein in human pancreatic cancer cells.". Cancer Res. 68 (7): 2065–70. doi:10.1158/0008-5472.CAN-07-6041. PMC 2835497. PMID 18381409. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2835497.