Asialoglycoprotein

Asialoglycoprotein

If terminal sialic acid residues are removed from glycoproteins, the resulting proteins are known as asialoglycoproteins.

These are transmembrane proteins where the amino terminal is cytosolic and the carboxyl terminal is exoplasmic.

These proteins have a single internal hydrophobic signal-anchor sequence that serves both as the endoplasmic reticulum signal peptide and a membrane-anchor sequence. The signal-anchor sequence is recognised by a Signal recognition particle (SRP) and is forced into the appropriate translocon to continue translation of the protein.

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Look at other dictionaries:

  • Asialoglycoprotein receptor — protein Name=asialoglycoprotein receptor 1 caption= width= HGNCid=742 Symbol=ASGR1 AltSymbols= EntrezGene=432 OMIM=108360 RefSeq=NM 001671 UniProt=P07306 PDB= ECnumber= Chromosome=17 Arm=p Band=13 LocusSupplementaryData= p11protein… …   Wikipedia

  • asialoglycoprotein — The carbohydrate moiety of many vertebrate glycoproteins bears terminal residues of sialic acid. If such residues are removed, eg. by treatment with a neuraminidase, the resulting proteins are known as asialoglycoproteins. In the case of certain… …   Dictionary of molecular biology

  • asialoglycoprotein — noun Any glycoprotein from which the sialic acid residues have been removed …   Wiktionary

  • asialoglycoprotein — A glycoprotein without a sialic acid moiety; such proteins are recognized by a. receptors and are targeted for degradation …   Medical dictionary

  • ASGP — asialoglycoprotein …   Medical dictionary

  • ASGP — • asialoglycoprotein …   Dictionary of medical acronyms & abbreviations

  • ASGR — asialoglycoprotein receptor …   Medical dictionary

  • ASGR — • asialoglycoprotein receptor …   Dictionary of medical acronyms & abbreviations

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