Opioid overdose

Opioid overdose
Classification and external resources
ICD-10	F11.0, T40.0-T40.2
ICD-9	305.5, 965.0
eMedicine	emerg/330

An opioid overdose is due to excessive use of narcotics.

It should not be confused with opioid dependency.

Symptoms

Opiate overdose symptoms and signs include: decreased level of consciousness and pinpoint pupil except with meperidine (Demerol) where one sees dilated pupils.

Treatment

Naloxone is very effective reversing the cause, rather than just the symptoms, of an opioid overdose.^[1] A longer-acting variant is naltrexone. Naltrexone is primarily meant to treat opioid and alcohol dependence. Diprenorphine is similar in action to naloxone, only it is significantly stronger and is reserved for acting as an antagonist to the strongest, non-human opioids, such as carfentanyl (in fact, carfentanyl, and other opioids for usage on large animals such as elephants, often come packaged with Revivon to be used after carfentanyl is no longer needed in the animal).

Co-ingestion

Opioid overdoses associated with a conjunction of benzodiazepines or alcohol use leads to a contraindicated condition wherein higher instances of general negative overdose traits native to the overdose profile of opioid use alone but to a much greater extent.^[2][3] Other CNS depressants, or "downers", muscle relaxers, pain relievers, anti-convulsants, anxiolytics (anti-anxiety drugs), treatment drugs of a psychoactive or epileptic variety or any other such drug with its active function meant to calm or mitigate neuronal signaling (barbiturates, etc) can additionally cause a worsened condition with less likelihood of recovery cumulative to each added drug of a diverse or disparate hampering effect to the central or peripheral nervous system of the user. This includes drugs less immediately classed to a slowing of the metabolism such as with GABAergics like GHB or glutamatergic antagonists like PCP or Ketamine.

References

1. ^ Etherington J, Christenson J, Innes G, et al. (July 2000). "Is early discharge safe after naloxone reversal of presumed opioid overdose?" (^{[dead link]}). CJEM 2 (3): 156–62. PMID 17621393. http://caep.ca/template.asp?id=8972217F485C4B5C84C49A4C617D2AC9. 
2. ^ "BestBets: Concomitant use of benzodiazepines in opiate overdose and the association with a poorer outcome.". http://www.bestbets.org/bets/bet.php?id=1007. 
3. ^ "BestBets: Concomitant use of alcohol in opiate overdose and the association with a poorer outcome.". http://www.bestbets.org/bets/bet.php?id=1006. 

This psychoactive drug-related article is a stub. You can help Wikipedia by expanding it.v · Categories: Psychoactive drug stubs Poisoning by drugs, medicaments and biological substances Wikimedia Foundation. 2010. Игры ⚽ Нужен реферат? Narcotic dermopathy Narcotica Look at other dictionaries: Opioid dependence — Opioid dependency Classification and external resources ICD 10 F11.2 …   Wikipedia Opioid — Endogenous opioid peptides Skeletal molecular images Adrenorphin Amidorphin Casomorphin …   Wikipedia Opioid antagonist — An opioid antagonist is a receptor antagonist that acts on opioid receptors. Naloxone and naltrexone are commonly used opioid antagonist drugs which are competitive antagonists that bind to the opioid receptors with higher affinity than agonists… …   Wikipedia Drug overdose — For other uses, see Overdose (disambiguation). Drug overdose Classification and external resources Activated charcoal is a commonly used agent for decontamination of the gastrointestinal tract in overdoses …   Wikipedia kappa Opioid receptor — Opioid receptor, kappa 1 Rendering based on PDB 2A0D …   Wikipedia mu Opioid receptor — Opioid receptor, mu 1 Identifiers Symbols OPRM1; KIAA0403; LMOR; MOR; MOR1; OPRM External IDs …   Wikipedia Mu Opioid receptor — The μ opioid receptors (MOR) are a class of opioid receptors with high affinity for enkephalins and beta endorphin but low affinity for dynorphins. The prototypical μ receptor agonist is the opium alkaloid morphine; μ (mu) refers to morphine.… …   Wikipedia Naloxone — Not to be confused with the related chemical naltrexone. Naloxone Systematic (IUPAC) name …   Wikipedia Laudanum — Combination of Morphine morphinan Codeine morphinan Thebaine morphinan Papaverine benzylisoquinoline Clinical data Pregna …   Wikipedia Substance dependence — Substance dependency Classification and external resources ICD 10 F10.2 F19.2 ICD 9 …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”