Drug-induced nonautoimmune hemolytic anemia

Drug-induced nonautoimmune hemolytic anemia
Drug-induced nonautoimmune hemolytic anemia
Classification and external resources
ICD-10 D59.2
ICD-9 283

Drug-induced nonautoimmune hemolytic anemia is a form of hemolytic anemia.

Non-immune drug induced hemolysis can occur via oxidative mechanisms. This is particularly likely to occur when there is an enzyme deficiency in the antioxidant defense system of the red blood cells. An example is where antimalarial oxidant drugs like primaquine[1] damage red blood cells in Glucose-6-phosphate dehydrogenase deficiency in which the red blood cells are more susceptible to oxidative stress due to reduced NADPH production consequent to the enzyme deficiency.

Some drugs cause RBC (red blood cell) lysis even in normal individuals. These include dapsone[2] and sulfasalazine.

Non-immune drug-induced hemolysis can also arise from drug-induced damage to cell volume control mechanisms; for example drugs can directly or indirectly impair regulatory volume decrease mechanisms, which become activated during hypotonic RBC swelling to return the cell to a normal volume. The consequence of the drugs actions are irreversible cell swelling and lysis (e.g. ouabain at very high doses).

See also

  • List of circulatory system conditions

References

  1. ^ Bowman ZS, Oatis JE, Whelan JL, Jollow DJ, McMillan DC (April 2004). "Primaquine-induced hemolytic anemia: susceptibility of normal versus glutathione-depleted rat erythrocytes to 5-hydroxyprimaquine". J. Pharmacol. Exp. Ther. 309 (1): 79–85. doi:10.1124/jpet.103.062984. PMID 14724225. http://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=14724225. 
  2. ^ Jollow DJ, Bradshaw TP, McMillan DC (1995). "Dapsone-induced hemolytic anemia". Drug Metab. Rev. 27 (1-2): 107–24. doi:10.3109/03602539509029818. PMID 7641572. 

Wikimedia Foundation. 2010.

Игры ⚽ Нужна курсовая?

Look at other dictionaries:

  • Drug-induced autoimmune hemolytic anemia — Classification and external resources ICD 10 D59.0 ICD 9 283 Drug induced au …   Wikipedia

  • Congenital hemolytic anemia — Classification and external resources ICD 10 D55 D58 ICD 9 …   Wikipedia

  • Microangiopathic hemolytic anemia — MAHA redirects here. For the governing body formerly known as Manitoba Amateur Hockey Association, see Hockey Manitoba. Microangiopathic hemolytic anemia Classification and external resources ICD 10 D59.4 ICD 9 …   Wikipedia

  • Anemia — For other uses, see Anemia (disambiguation). Anemia Classification and external resources ICD 10 D50 D64 ICD 9 …   Wikipedia

  • Pernicious anemia — Classification and external resources ICD 10 D51.0 ICD 9 281.0 …   Wikipedia

  • Megaloblastic anemia — Classification and external resources Peripheral blood smear showing hypersegmented neutrophils, characteristic of megaloblastic anemia. ICD 10 D …   Wikipedia

  • Normochromic anemia — Normochromic is a form of anemia in which the concentration of hemoglobin in the red blood cells is within the standard range. However, there are insufficient numbers of red blood cells. This includes: aplastic, posthemorrhagic, and hemolytic… …   Wikipedia

  • Microcytic anemia — Classification and external resources ICD 10 D50.8 Microcytic anemia (BrE: anaemia) is a generic term for any type of anemia characterized by small red blood cells. The normal mean corp …   Wikipedia

  • Diamond–Blackfan anemia — Classification and external resources ICD 10 D61.0 ICD 9 284.01 …   Wikipedia

  • Normocytic anemia — is a common issue that occurs for men and women typically over 85 years old. Its prevalence increases with age, reaching 44 percent in men older than 85 years.[1] Normocytic anemia is the most frequently encountered type of anemia.[1] Contents 1… …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”