- Hyperprothrombinemia
Infobox_Disease
Name = PAGENAME
Caption =
DiseasesDB = 32790
ICD10 =
ICD9 =
ICDO =
OMIM = 176930
MedlinePlus =
eMedicineSubj =
eMedicineTopic =
MeshID =Hyperprothrombinemia is a disorder of
prothrombin which leads to hypercoagulation.Substitution of
adenine forguanine at position 20210 of theprothrombin gene, known as the prothrombin 20210a mutation, prothrombin 20210 mutation and, less precise, just factor II mutation, [Steen CJ. Factor II. eMedicine.com. URL: [http://www.emedicine.com/med/topic3494.htm http://www.emedicine.com/med/topic3494.htm] . Accessed on: March 11, 2007.] cite journal |author=Varga E, Moll S |title=Cardiology patient pages. Prothrombin 20210 mutation (factor II mutation) |journal=Circulation |volume=110 |issue=3 |pages=e15–8 |year=2004 |pmid=15262854 |doi=10.1161/01.CIR.0000135582.53444.87 [http://circ.ahajournals.org/cgi/content/full/110/3/e15 Free Full Text] .] leads tohypercoagulability and may be a factor that contributes toinfertility . Its prevalence is thought to be approximately 2% in caucasians and 0.5% in blacks.Position 20210 falls outside of the
reading frame for the protein and is thought to play a role in promoting prothrombin production; the substitution leads to high levels of prothrombin. [cite journal |author=Poort S, Rosendaal F, Reitsma P, Bertina R |title=A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis |journal=Blood |volume=88 |issue=10 |pages=3698–703 |year=1996 |pmid=8916933|url=http://bloodjournal.hematologylibrary.org/cgi/reprint/88/10/3698.pdf]References
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