- Haemophilia C
Infobox_Disease
Name = PAGENAME
Caption =
DiseasesDB = 29376
ICD10 = ICD10|D|68|1|d|65
ICD9 = ICD9|286.2
ICDO =
OMIM = 264900
MedlinePlus =
eMedicineSubj = ped
eMedicineTopic = 964
eMedicine_mult = eMedicine2|med|3515
MeshID = D005173Haemophilia C is a mild form of
haemophilia affecting both sexes. However, it predominantly occurs in Jews ofAshkenazi descent. It is the fourth most commoncoagulation disorder aftervon Willebrand's disease andhaemophilia A and B. [http://www.gpnotebook.co.uk/cache/-885719013.htm] In theUSA it is thought to affect 1 in 100,000 of the adult population, making it 10% less common than haemophilia A. [ [http://www.emedicine.com/ped/topic964.htm eMedicine - Hemophilia C : Article by Prasad Mathew, MBBS, DCH ] ]It is caused by a deficiency of
coagulation factor XI and is distinguished from haemophilia A and B by the fact it does not lead to bleeding into the joints. Furthermore, it hasautosomal recessive inheritance, since the gene for factor XI is located on chromosome 4 (close to the prekallikrein gene). Many mutations exist, and the bleeding risk is not always influenced by the severity of the deficiency. Treatment is usually not necessary, except in relation to operations, leading to many of those having the condition not being aware of it. In these cases,fresh frozen plasma or recombinant factor XI may be used, but only if necessary. The afflicted may often suffer nosebleeds, and females can experience heavymenstrual bleeding . [ [http://www.haemophilia.org.uk/index.php?content_id=91&parent=278 Key facts: other bleeding disorders ] ] Hemophaelia C was first discovered in a young Ashkenazic Jewish American in the 1950s.ymptoms
The symptoms of Haemophilia C are the same as those for other forms of Haemophilia, mainly: [ [http://www.doctorndtv.com/topics/searchdetailtopics.asp?id=528 Haemophilia | DoctorNDTV: Health Information on Haemophilia ] ]
*Prolonged bleeding from injuries.
*Frequent or heavy nosebleeds.
*Traces of blood in the urine.ee also
*
Haemophilia
*Haemophilia A
*Haemophilia B References
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