- Sideroblastic anemia
* With
lead poisoning , see coarse basophilic stippling of red blood cells on peripheral blood smear
* Specific test: Prussian Blue stain of RBC in marrow. Shows ringed sideroblasts.Treatment
Occasionally, the anemia is so severe that support with transfusion is required. These patients usually do not respond to
erythropoietin therapy. [cite book |author=Papadakis, Maxine A.; Tierney, Lawrence M.; McPhee, Stephen J. |title=Current Medical Diagnosis & Treatment, 2006 |publisher=McGraw-Hill Medical |location= |year=2005 |pages= |chapter=Sideroblastic Anemia |isbn=0-07-145410-1 |oclc= |doi= |accessdate=] Some cases have been reported that the anemia is reversed or heme level is improved through use of moderate to high doses of pyrodoxine (Vitamin B6.) In severe cases of SBA, bone marrow transplant is also an option with limited information about the success rate. Some cases are listed on MedLine and various other medical sites. In the case ofisoniazid -induced sideroblastic anemia, the addition of B6 is sufficient to correct the anemia.ee also
*
Anemia
*Siderosis References
External links
* [http://sickle.bwh.harvard.edu/sideroblastic.html Sideroblastic Anemias: Introduction - Information Center for Sickle Cell and Thalassemic Disorders ]
* [http://www.irondisorders.org/Disorders/Sideroblastic.asp A concise description of this group of diseases from the Iron Disorders Institute]
*RareDiseases|667|Anemia, Sideroblastic
*OMIM3|301310 RareDiseases|668|Anemia, sideroblastic spinocerebellar ataxia
*OMIM3|269950 RareDiseases|7644|Sideroblastic anemia, autosomal
*OMIM3|301300 RareDiseases|9456|X-linked sideroblastic anemia
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