Drug-induced autoimmune hemolytic anemia

Drug-induced autoimmune hemolytic anemia: Drug-induced autoimmune hemolytic anemia

Classification and external resources

ICD-10 D59.0

ICD-9 283

Drug-induced autoimmune hemolytic anemia is a form of hemolytic anemia.

Penicillin in high doses can induce immune mediated hemolysis^[1] via the hapten mechanism in which antibodies are targeted against the combination of penicillin in association with red blood cells. Complement is activated by the attached antibody leading to the removal of red blood cells by the spleen.

The drug itself can be targeted by the immune system, e.g. by IgE in a Type I hypersensitivity reaction to penicillin, rarely leading to anaphylaxis.

See also

List of circulatory system conditions

List of hematologic conditions

References

^ Stroncek D, Procter JL, Johnson J (May 2000). "Drug-induced hemolysis: cefotetan-dependent hemolytic anemia mimicking an acute intravascular immune transfusion reaction". Am. J. Hematol. 64 (1): 67–70. doi:10.1002/(SICI)1096-8652(200005)64:1<67::AID-AJH12>3.0.CO;2-Z. PMID 10815791.

v · d · ePathology: hematology · hematologic diseases of RBCs and megakaryocytes / MEP (D50-69,74, 280-287)

Red
blood cells

↑

Poly-
cythemia

Polycythemia vera

↓

Anemia

Nutritional

Micro-: Iron deficiency anemia (Plummer-Vinson syndrome)
Macro-: Megaloblastic anemia (Pernicious anemia)

Hemolytic
(mostly Normo-)

Hereditary

enzymopathy: G6PD · glycolysis (PK, TI, HK)

hemoglobinopathy: Thalassemia (alpha, beta, delta) · Sickle-cell disease/trait · HPFH
membrane: Hereditary spherocytosis (Minkowski-Chauffard syndrome) · Hereditary elliptocytosis (Southeast Asian ovalocytosis) · Hereditary stomatocytosis

Acquired

Autoimmune (WAHA, CAD, PCH)

membrane (PNH)

MAHA · TM (HUS)

Drug-induced autoimmune · Drug-induced nonautoimmune
Hemolytic disease of the newborn

Aplastic
(mostly Normo-)

Hereditary: Fanconi anemia · Diamond–Blackfan anemia
Acquired: PRCA · Sideroblastic anemia · Myelophthisic

Blood tests

MCV (Normocytic, Microcytic, Macrocytic) · MCHC (Normochromic, Hypochromic)

Other

Methemoglobinemia · Sulfhemoglobinemia · Reticulocytopenia

Coagulation/
coagulopathy

↑

Hyper-
coagulability

primary: Antithrombin III deficiency · Protein C deficiency/Activated protein C resistance/Protein S deficiency/Factor V Leiden · Hyperprothrombinemia
acquired:Thrombocytosis (essential) · DIC (Congenital afibrinogenemia, Purpura fulminans) · autoimmune (Antiphospholipid)

↓

Hypo-
coagulability

Thrombocytopenia

Thrombocytopenic purpura: ITP (Evans syndrome) · TM (TTP)
Heparin-induced thrombocytopenia · May-Hegglin anomaly

Platelet function

adhesion (Bernard–Soulier syndrome) · aggregation (Glanzmann's thrombasthenia) · platelet storage pool deficiency (Hermansky–Pudlak syndrome, Gray platelet syndrome)

Clotting factor

Hemophilia (A/VIII, B/IX, C/XI) • Von Willebrand disease • Hypoprothrombinemia/II · XIII · Dysfibrinogenemia

M: MYL

cell/phys (coag, heme, immu, gran), csfs

rbmg/mogr/tumr/hist, sysi/epon, btst

drug (B1/2/3+5+6), btst, trns

Categories:
Acquired hemolytic anemia

Drug-induced autoimmune hemolytic anemia
Classification and external resources
ICD-10	D59.0
ICD-9	283

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Drug-induced autoimmune hemolytic anemia

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Drug-induced autoimmune hemolytic anemia

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