Hypoprothrombinemia

Infobox_Disease
Name = PAGENAME


Caption =
DiseasesDB =
ICD10 =
ICD9 = ICD9|286.3, ICD9|776.3
ICDO =
OMIM =
MedlinePlus =
eMedicineSubj = ped
eMedicineTopic = 1133
MeshID = D007020

Hypoprothrombinemia is a blood disorder in which a deficiency of prothrombin (Factor II) results in impaired blood clotting, leading to an increased physiological risk for bleeding, especially in the gastrointestinal system, cranial vault, and superficial integumentary system.

Causes

Hypoprothrombinemia can be the result of a genetic defect or it may be acquired as the result of another disease process, or an adverse effect of medication. For example, 5-10% of patients with Systemic lupus erythematosus exhibit acquired hypoprothrombinemia due to the presence of autoantibodies which bind to prothrombin and remove it from the bloodstream (lupus anticoagulant-hypoprothrombinaemia syndrome). [cite journal | author = Bajaj S, Rapaport S, Fierer D, Herbst K, Schwartz D | title = A mechanism for the hypoprothrombinemia of the acquired hypoprothrombinemia-lupus anticoagulant syndrome. | journal = Blood | volume = 61 | issue = 4 | pages = 684–92 | year = 1983 | pmid = 6403077]

Treatment

Hypoprothrombinemia can be treated with periodic infusions of purified prothrombin complexes. [cite journal | author = Lechler E | title = Use of prothrombin complex concentrates for prophylaxis and treatment of bleeding episodes in patients with hereditary deficiency of prothrombin, factor VII, factor X, protein C protein S, or protein Z. | journal = Thromb Res | volume = 95 | issue = 4 Suppl 1 | pages = S39–50 | year = 1999 | pmid = 10499908 | doi = 10.1016/S0049-3848(99)00083-3]

References