- OR5I1
-
Olfactory receptor, family 5, subfamily I, member 1 Identifiers Symbols OR5I1; HSOlf1; OLF1 External IDs OMIM: 608496 MGI: 1313139 HomoloGene: 4835 GeneCards: OR5I1 Gene Gene Ontology Molecular function • receptor activity
• olfactory receptor activityCellular component • plasma membrane
• integral to membraneBiological process • signal transduction
• sensory perception of smell
• response to stimulusSources: Amigo / QuickGO RNA expression pattern 
More reference expression data Orthologs Species Human Mouse Entrez 10798 258640 Ensembl ENSG00000167825 ENSMUSG00000068816 UniProt Q13606 n/a RefSeq (mRNA) NM_006637 NM_146646.2 RefSeq (protein) NP_006628 NP_666857.2 Location (UCSC) Chr 11:
55.7 – 55.7 MbChr 2:
87.62 – 87.62 MbPubMed search [1] [2] Olfactory receptor 5I1 is a protein that in humans is encoded by the OR5I1 gene.[1][2][3]
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[3]
Contents
See also
References
- ^ Issel-Tarver L, Rine J (Apr 1997). "The Evolution of Mammalian Olfactory Receptor Genes". Genetics 145 (1): 185–95. PMC 1207777. PMID 9017400. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1207777.
- ^ Buettner JA, Glusman G, Ben-Arie N, Ramos P, Lancet D, Evans GA (Dec 1998). "Organization and evolution of olfactory receptor genes on human chromosome 11". Genomics 53 (1): 56–68. doi:10.1006/geno.1998.5422. PMID 9787077.
- ^ a b "Entrez Gene: OR5I1 olfactory receptor, family 5, subfamily I, member 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10798.
Further reading
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=356993.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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- Transmembrane receptor stubs
- G protein coupled receptors
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