- OR4E2
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Olfactory receptor, family 4, subfamily E, member 2 Identifiers Symbols OR4E2; OR14-42 External IDs MGI: 3031343 HomoloGene: 41378 GeneCards: OR4E2 Gene Gene Ontology Molecular function • receptor activity
• olfactory receptor activityCellular component • plasma membrane
• integral to membraneBiological process • sensory perception of smell
• response to stimulusSources: Amigo / QuickGO Orthologs Species Human Mouse Entrez 26686 57271 Ensembl ENSG00000221977 ENSMUSG00000035626 UniProt Q8NGC2 n/a RefSeq (mRNA) NM_001001912 NM_020514.2 RefSeq (protein) NP_001001912 NP_065260.2 Location (UCSC) Chr 14:
22.13 – 22.13 MbChr 14:
53.07 – 53.07 MbPubMed search [1] [2] Olfactory receptor 4E2 is a protein that in humans is encoded by the OR4E2 gene.[1]
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[1]
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References
Further reading
- Koop BF, Rowen L, Wang K, et al. (1994). "The human T-cell receptor TCRAC/TCRDC (C alpha/C delta) region: organization, sequence, and evolution of 97.6 kb of DNA.". Genomics 19 (3): 478–93. doi:10.1006/geno.1994.1097. PMID 8188290.
- Boysen C, Simon MI, Hood L (1997). "Analysis of the 1.1-Mb human alpha/delta T-cell receptor locus with bacterial artificial chromosome clones.". Genome Res. 7 (4): 330–8. doi:10.1101/gr.7.4.330. PMID 9110172.
- Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes.". Genomics 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID 12213199.
- Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family.". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=356993.
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
Class II
(tetrapod specific receptors)Family 1Family 2A1 · A2 · A4 · A5 · A7 · A12 · A14 · A25 · A42 · AE1 · AG1 · AG2 · AJ1 · AK2 · AP1 · AT4 · B2 · B3 · B6 · B8 · B11 · C1 · C3 · D2 · D3 · F1 · F2 · G2 · G3 · G6 · H1 · H2 · J1 · J2 · J3 · K2 · L2 · L3 · L5 · L8 · L13 · M2 · M3 · M4 · M5 · M7 · S2 · T1 · T2 · T3 · T4 · T5 · T6 · T8 · T10 · T11 · T12 · T27 · T29 · T33 · T34 · T35 · V1 · V2 · W1 · W3 · W5 · Y1 · Z1
Family 3Family 4Family 5Family 6Family 7Family 8Family 9Family 10Family 11Family 12Family 13Categories:- Human proteins
- Transmembrane receptor stubs
- G protein coupled receptors
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