- OR1E2
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Olfactory receptor, family 1, subfamily E, member 2 Identifiers Symbols OR1E2; OR17-135; OR17-93; OR1E4; OR1E7; OST529 External IDs MGI: 109312 HomoloGene: 74111 GeneCards: OR1E2 Gene Gene Ontology Molecular function • receptor activity
• olfactory receptor activityCellular component • plasma membrane
• integral to plasma membraneBiological process • signal transduction
• sensory perception of chemical stimulus
• sensory perception of smell
• response to stimulusSources: Amigo / QuickGO RNA expression pattern 
More reference expression data Orthologs Species Human Mouse Entrez 8388 258924 Ensembl ENSG00000127780 ENSMUSG00000063881 UniProt P47887 n/a RefSeq (mRNA) NM_003554 NM_010970 RefSeq (protein) NP_003545 NP_035100 Location (UCSC) Chr 17:
3.34 – 3.34 MbChr 11:
73.18 – 73.19 MbPubMed search [1] [2] Olfactory receptor 1E2 is a protein that in humans is encoded by the OR1E2 gene.[1][2][3]
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[3]
Contents
See also
References
- ^ Ben-Arie N, Lancet D, Taylor C, Khen M, Walker N, Ledbetter DH, Carrozzo R, Patel K, Sheer D, Lehrach H, et al. (Jul 1994). "Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire". Hum Mol Genet 3 (2): 229–35. doi:10.1093/hmg/3.2.229. PMID 8004088.
- ^ Rouquier S, Taviaux S, Trask BJ, Brand-Arpon V, van den Engh G, Demaille J, Giorgi D (Mar 1998). "Distribution of olfactory receptor genes in the human genome". Nat Genet 18 (3): 243–50. doi:10.1038/ng0398-243. PMID 9500546.
- ^ a b "Entrez Gene: OR1E2 olfactory receptor, family 1, subfamily E, member 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8388.
Further reading
- Gotschlich EC (1975). "Development of polysaccharide vaccines for the prevention of meningococcal diseases". Monographs in allergy 9: 245–58. PMID 804088.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=356993.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes". Genomics 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID 12213199.
- Glusman G, Sosinsky A, Ben-Asher E, et al. (2000). "Sequence, structure, and evolution of a complete human olfactory receptor gene cluster". Genomics 63 (2): 227–45. doi:10.1006/geno.1999.6030. PMID 10673334.
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
Class II
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- Transmembrane receptor stubs
- G protein coupled receptors
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