- OR4F4
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Olfactory receptor, family 4, subfamily F, member 4 Identifiers Symbols OR4F4; OLA-7501; OR4F18 External IDs HomoloGene: 88360 GeneCards: OR4F4 Gene Gene Ontology Molecular function • receptor activity
• olfactory receptor activityCellular component • plasma membrane
• integral to membraneBiological process • sensory perception of smell
• response to stimulusSources: Amigo / QuickGO Orthologs Species Human Mouse Entrez 26682 258395 Ensembl ENSG00000177693 ENSMUSG00000044039 UniProt Q8NH21 n/a RefSeq (mRNA) NM_001004195 NM_146400.2 RefSeq (protein) NP_001004195 NP_666512.2 Location (UCSC) Chr 15:
102.46 – 102.46 MbChr 2:
111.32 – 111.32 MbPubMed search [1] [2] Olfactory receptor 4F4 is a protein that in humans is encoded by the OR4F4 gene.[1]
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[1]
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References
Further reading
- Trask BJ, Friedman C, Martin-Gallardo A, et al. (1998). "Members of the olfactory receptor gene family are contained in large blocks of DNA duplicated polymorphically near the ends of human chromosomes.". Hum. Mol. Genet. 7 (1): 13–26. doi:10.1093/hmg/7.1.13. PMID 9384599.
- Mefford HC, Linardopoulou E, Coil D, et al. (2002). "Comparative sequencing of a multicopy subtelomeric region containing olfactory receptor genes reveals multiple interactions between non-homologous chromosomes.". Hum. Mol. Genet. 10 (21): 2363–72. doi:10.1093/hmg/10.21.2363. PMID 11689483.
- Linardopoulou E, Mefford HC, Nguyen O, et al. (2002). "Transcriptional activity of multiple copies of a subtelomerically located olfactory receptor gene that is polymorphic in number and location.". Hum. Mol. Genet. 10 (21): 2373–83. doi:10.1093/hmg/10.21.2373. PMID 11689484.
- Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes.". Genomics 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID 12213199.
- Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family.". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=356993.
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
Class II
(tetrapod specific receptors)Family 1Family 2A1 · A2 · A4 · A5 · A7 · A12 · A14 · A25 · A42 · AE1 · AG1 · AG2 · AJ1 · AK2 · AP1 · AT4 · B2 · B3 · B6 · B8 · B11 · C1 · C3 · D2 · D3 · F1 · F2 · G2 · G3 · G6 · H1 · H2 · J1 · J2 · J3 · K2 · L2 · L3 · L5 · L8 · L13 · M2 · M3 · M4 · M5 · M7 · S2 · T1 · T2 · T3 · T4 · T5 · T6 · T8 · T10 · T11 · T12 · T27 · T29 · T33 · T34 · T35 · V1 · V2 · W1 · W3 · W5 · Y1 · Z1
Family 3Family 4Family 5Family 6Family 7Family 8Family 9Family 10Family 11Family 12Family 13Categories:- Human proteins
- Transmembrane receptor stubs
- G protein coupled receptors
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