- OR10A5
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Olfactory receptor, family 10, subfamily A, member 5 Identifiers Symbols OR10A5; JCG6; OR10A1; OR11-403 External IDs OMIM: 608493 MGI: 3030547 HomoloGene: 17470 GeneCards: OR10A5 Gene Gene Ontology Molecular function • receptor activity
• olfactory receptor activityCellular component • plasma membrane
• integral to membraneBiological process • sensory perception of smell
• response to stimulusSources: Amigo / QuickGO Orthologs Species Human Mouse Entrez 144124 259036 Ensembl ENSG00000166363 ENSMUSG00000073898 UniProt Q9H207 n/a RefSeq (mRNA) NM_178168 NM_147034.1 RefSeq (protein) NP_835462 NP_667245.1 Location (UCSC) Chr 11:
6.87 – 6.87 MbChr 7:
114.18 – 114.18 MbPubMed search [1] [2] Olfactory receptor 10A5 is a protein that in humans is encoded by the OR10A5 gene.[1]
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[1]
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References
Further reading
- Buettner JA, Glusman G, Ben-Arie N, et al. (1998). "Organization and evolution of olfactory receptor genes on human chromosome 11.". Genomics 53 (1): 56–68. doi:10.1006/geno.1998.5422. PMID 9787077.
- Lane RP, Cutforth T, Young J, et al. (2001). "Genomic analysis of orthologous mouse and human olfactory receptor loci.". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7390–5. doi:10.1073/pnas.131215398. PMC 34679. PMID 11416212. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=34679.
- Gaudin JC, Breuils L, Haertlé T (2002). "New GPCRs from a human lingual cDNA library.". Chem. Senses 26 (9): 1157–66. doi:10.1093/chemse/26.9.1157. PMID 11705801.
- Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes.". Genomics 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID 12213199.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family.". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=356993.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
Class II
(tetrapod specific receptors)Family 1Family 2A1 · A2 · A4 · A5 · A7 · A12 · A14 · A25 · A42 · AE1 · AG1 · AG2 · AJ1 · AK2 · AP1 · AT4 · B2 · B3 · B6 · B8 · B11 · C1 · C3 · D2 · D3 · F1 · F2 · G2 · G3 · G6 · H1 · H2 · J1 · J2 · J3 · K2 · L2 · L3 · L5 · L8 · L13 · M2 · M3 · M4 · M5 · M7 · S2 · T1 · T2 · T3 · T4 · T5 · T6 · T8 · T10 · T11 · T12 · T27 · T29 · T33 · T34 · T35 · V1 · V2 · W1 · W3 · W5 · Y1 · Z1
Family 3Family 4Family 5Family 6Family 7Family 8Family 9Family 10Family 11Family 12Family 13Categories:- Human proteins
- Transmembrane receptor stubs
- G protein coupled receptors
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