UPK1A

Uroplakin 1A, also known as UPK1A, is a human gene.cite web | title = Entrez Gene: UPK1A uroplakin 1A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11045| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions.cite web | title = Entrez Gene: UPK1A uroplakin 1A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11045| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Berditchevski F |title=Complexes of tetraspanins with integrins: more than meets the eye. |journal=J. Cell. Sci. |volume=114 |issue= Pt 23 |pages= 4143–51 |year= 2002 |pmid= 11739647 |doi=
*cite journal | author=Yu J, Lin JH, Wu XR, Sun TT |title=Uroplakins Ia and Ib, two major differentiation products of bladder epithelium, belong to a family of four transmembrane domain (4TM) proteins. |journal=J. Cell Biol. |volume=125 |issue= 1 |pages= 171–82 |year= 1994 |pmid= 8138569 |doi=
*cite journal | author=Wu XR, Medina JJ, Sun TT |title=Selective interactions of UPIa and UPIb, two members of the transmembrane 4 superfamily, with distinct single transmembrane-domained proteins in differentiated urothelial cells. |journal=J. Biol. Chem. |volume=270 |issue= 50 |pages= 29752–9 |year= 1996 |pmid= 8530366 |doi=
*cite journal | author=Lobban ED, Smith BA, Hall GD, "et al." |title=Uroplakin gene expression by normal and neoplastic human urothelium. |journal=Am. J. Pathol. |volume=153 |issue= 6 |pages= 1957–67 |year= 1998 |pmid= 9846985 |doi=
*cite journal | author=Yuasa T, Yoshiki T, Isono T, "et al." |title=Expression of transitional cell-specific genes, uroplakin Ia and II, in bladder cancer: detection of circulating cancer cells in the peripheral blood of metastatic patients. |journal=Int. J. Urol. |volume=6 |issue= 6 |pages= 286–92 |year= 1999 |pmid= 10404304 |doi=
*cite journal | author=Ogawa K, Johansson SL, Cohen SM |title=Immunohistochemical analysis of uroplakins, urothelial specific proteins, in ovarian Brenner tumors, normal tissues, and benign and neoplastic lesions of the female genital tract. |journal=Am. J. Pathol. |volume=155 |issue= 4 |pages= 1047–50 |year= 1999 |pmid= 10514386 |doi=
*cite journal | author=Kageyama S, Yoshiki T, Isono T, "et al." |title=High expression of human uroplakin Ia in urinary bladder transitional cell carcinoma. |journal=Jpn. J. Cancer Res. |volume=93 |issue= 5 |pages= 523–31 |year= 2003 |pmid= 12036448 |doi=
*cite journal | author=Tu L, Sun TT, Kreibich G |title=Specific heterodimer formation is a prerequisite for uroplakins to exit from the endoplasmic reticulum. |journal=Mol. Biol. Cell |volume=13 |issue= 12 |pages= 4221–30 |year= 2003 |pmid= 12475947 |doi= 10.1091/mbc.E02-04-0211
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Grimwood J, Gordon LA, Olsen A, "et al." |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529–35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399
*cite journal | author=Yuasa T, Yoshiki T, Isono T, "et al." |title=Molecular cloning and expression of uroplakins in transitional cell carcinoma. |journal=Adv. Exp. Med. Biol. |volume=539 |issue= Pt A |pages= 33–46 |year= 2004 |pmid= 15088894 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Hall GD, Weeks RJ, Olsburgh J, "et al." |title=Transcriptional control of the human urothelial-specific gene, uroplakin Ia. |journal=Biochim. Biophys. Acta |volume=1729 |issue= 2 |pages= 126–34 |year= 2005 |pmid= 15913809 |doi= 10.1016/j.bbaexp.2005.04.004

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