RIPK3

Receptor-interacting serine-threonine kinase 3, also known as RIPK3, is a human gene.cite web | title = Entrez Gene: RIPK3 receptor-interacting serine-threonine kinase 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11035| accessdate = ]

PBB_Summary
section_title =
summary_text = The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor.cite web | title = Entrez Gene: RIPK3 receptor-interacting serine-threonine kinase 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11035| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Yu PW, Huang BC, Shen M, "et al." |title=Identification of RIP3, a RIP-like kinase that activates apoptosis and NFkappaB. |journal=Curr. Biol. |volume=9 |issue= 10 |pages= 539–42 |year= 1999 |pmid= 10339433 |doi=
*cite journal | author=Sun X, Lee J, Navas T, "et al." |title=RIP3, a novel apoptosis-inducing kinase. |journal=J. Biol. Chem. |volume=274 |issue= 24 |pages= 16871–5 |year= 1999 |pmid= 10358032 |doi=
*cite journal | author=Kasof GM, Prosser JC, Liu D, "et al." |title=The RIP-like kinase, RIP3, induces apoptosis and NF-kappaB nuclear translocation and localizes to mitochondria. |journal=FEBS Lett. |volume=473 |issue= 3 |pages= 285–91 |year= 2000 |pmid= 10818227 |doi=
*cite journal | author=Sun X, Yin J, Starovasnik MA, "et al." |title=Identification of a novel homotypic interaction motif required for the phosphorylation of receptor-interacting protein (RIP) by RIP3. |journal=J. Biol. Chem. |volume=277 |issue= 11 |pages= 9505–11 |year= 2002 |pmid= 11734559 |doi= 10.1074/jbc.M109488200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Bouwmeester T, Bauch A, Ruffner H, "et al." |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97–105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086
*cite journal | author=Meylan E, Burns K, Hofmann K, "et al." |title=RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation. |journal=Nat. Immunol. |volume=5 |issue= 5 |pages= 503–7 |year= 2004 |pmid= 15064760 |doi= 10.1038/ni1061
*cite journal | author=Yang Y, Ma J, Chen Y, Wu M |title=Nucleocytoplasmic shuttling of receptor-interacting protein 3 (RIP3): identification of novel nuclear export and import signals in RIP3. |journal=J. Biol. Chem. |volume=279 |issue= 37 |pages= 38820–9 |year= 2004 |pmid= 15208320 |doi= 10.1074/jbc.M401663200
*cite journal | author=Yang Y, Hu W, Feng S, "et al." |title=RIP3 beta and RIP3 gamma, two novel splice variants of receptor-interacting protein 3 (RIP3), downregulate RIP3-induced apoptosis. |journal=Biochem. Biophys. Res. Commun. |volume=332 |issue= 1 |pages= 181–7 |year= 2005 |pmid= 15896315 |doi= 10.1016/j.bbrc.2005.04.114
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406
*cite journal | author=Zhao L, Wang G, Lu D, "et al." |title=Homocysteine, hRIP3 and congenital cardiovascular malformations. |journal=Anat. Embryol. |volume=211 |issue= 3 |pages= 203–12 |year= 2006 |pmid= 16429275 |doi= 10.1007/s00429-005-0074-9
*cite journal | author=Feng S, Ma L, Yang Y, Wu M |title=Truncated RIP3 (tRIP3) acts upstream of FADD to induce apoptosis in the human hepatocellular carcinoma cell line QGY-7703. |journal=Biochem. Biophys. Res. Commun. |volume=347 |issue= 3 |pages= 558–65 |year= 2006 |pmid= 16844082 |doi= 10.1016/j.bbrc.2006.06.118
*cite journal | author=Ahn KS, Sethi G, Krishnan K, Aggarwal BB |title=Gamma-tocotrienol inhibits nuclear factor-kappaB signaling pathway through inhibition of receptor-interacting protein and TAK1 leading to suppression of antiapoptotic gene products and potentiation of apoptosis. |journal=J. Biol. Chem. |volume=282 |issue= 1 |pages= 809–20 |year= 2007 |pmid= 17114179 |doi= 10.1074/jbc.M610028200

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