PPP1R13B

Protein phosphatase 1, regulatory (inhibitor) subunit 13B, also known as PPP1R13B, is a human gene.cite web | title = Entrez Gene: PPP1R13B protein phosphatase 1, regulatory (inhibitor) subunit 13B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23368| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor.cite web | title = Entrez Gene: PPP1R13B protein phosphatase 1, regulatory (inhibitor) subunit 13B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23368| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Liu ZJ, Lu X, Zhong S |title=ASPP--Apoptotic specific regulator of p53. |journal=Biochim. Biophys. Acta |volume=1756 |issue= 1 |pages= 77–80 |year= 2005 |pmid= 16139958 |doi= 10.1016/j.bbcan.2005.08.002
*cite journal | author=Nagase T, Ishikawa K, Suyama M, "et al." |title=Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 5 |pages= 277–86 |year= 1999 |pmid= 9872452 |doi=
*cite journal | author=Samuels-Lev Y, O'Connor DJ, Bergamaschi D, "et al." |title=ASPP proteins specifically stimulate the apoptotic function of p53. |journal=Mol. Cell |volume=8 |issue= 4 |pages= 781–94 |year= 2001 |pmid= 11684014 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Heilig R, Eckenberg R, Petit JL, "et al." |title=The DNA sequence and analysis of human chromosome 14. |journal=Nature |volume=421 |issue= 6923 |pages= 601–7 |year= 2003 |pmid= 12508121 |doi= 10.1038/nature01348
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Bergamaschi D, Samuels Y, Jin B, "et al." |title=ASPP1 and ASPP2: common activators of p53 family members. |journal=Mol. Cell. Biol. |volume=24 |issue= 3 |pages= 1341–50 |year= 2004 |pmid= 14729977 |doi=
*cite journal | author=Colland F, Jacq X, Trouplin V, "et al." |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104
*cite journal | author=Hershko T, Chaussepied M, Oren M, Ginsberg D |title=Novel link between E2F and p53: proapoptotic cofactors of p53 are transcriptionally upregulated by E2F. |journal=Cell Death Differ. |volume=12 |issue= 4 |pages= 377–83 |year= 2005 |pmid= 15706352 |doi= 10.1038/sj.cdd.4401575
*cite journal | author=Fogal V, Kartasheva NN, Trigiante G, "et al." |title=ASPP1 and ASPP2 are new transcriptional targets of E2F. |journal=Cell Death Differ. |volume=12 |issue= 4 |pages= 369–76 |year= 2005 |pmid= 15731768 |doi= 10.1038/sj.cdd.4401562
*cite journal | author=Liu ZJ, Lu X, Zhang Y, "et al." |title=Downregulated mRNA expression of ASPP and the hypermethylation of the 5'-untranslated region in cancer cell lines retaining wild-type p53. |journal=FEBS Lett. |volume=579 |issue= 7 |pages= 1587–90 |year= 2005 |pmid= 15757645 |doi= 10.1016/j.febslet.2005.01.069
*cite journal | author=Bergamaschi D, Samuels Y, Zhong S, Lu X |title=Mdm2 and mdmX prevent ASPP1 and ASPP2 from stimulating p53 without targeting p53 for degradation. |journal=Oncogene |volume=24 |issue= 23 |pages= 3836–41 |year= 2005 |pmid= 15782125 |doi= 10.1038/sj.onc.1208535
*cite journal | author=Agirre X, Román-Gómez J, Jiménez-Velasco A, "et al." |title=ASPP1, a common activator of TP53, is inactivated by aberrant methylation of its promoter in acute lymphoblastic leukemia. |journal=Oncogene |volume=25 |issue= 13 |pages= 1862–70 |year= 2006 |pmid= 16314841 |doi= 10.1038/sj.onc.1209236

PBB_Controls
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