AKAP10

A kinase (PRKA) anchor protein 10, also known as AKAP10, is a human gene.cite web | title = Entrez Gene: AKAP10 A kinase (PRKA) anchor protein 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11216| accessdate = ]

PBB_Summary
section_title =
summary_text = The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein interacts with both the type I and type II regulatory subunits of PKA; therefore, it is a dual-specific AKAP. This protein is highly enriched in mitochondria. It contains RGS (regulator of G protein signalling) domains, in addition to a PKA-RII subunit-binding domain. The mitochondrial localization and the presence of RGS domains may have important implications for the function of this protein in PKA and G protein signal transduction.cite web | title = Entrez Gene: AKAP10 A kinase (PRKA) anchor protein 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11216| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Lester LB, Scott JD |title=Anchoring and scaffold proteins for kinases and phosphatases. |journal=Recent Prog. Horm. Res. |volume=52 |issue= |pages= 409–29; discussion 429–30 |year= 1997 |pmid= 9238861 |doi=
*cite journal | author=Michel JJ, Scott JD |title=AKAP mediated signal transduction. |journal=Annu. Rev. Pharmacol. Toxicol. |volume=42 |issue= |pages= 235–57 |year= 2002 |pmid= 11807172 |doi= 10.1146/annurev.pharmtox.42.083101.135801
*cite journal | author=Epplen C, Epplen JT |title=Expression of (cac)n/(gtg)n simple repetitive sequences in mRNA of human lymphocytes. |journal=Hum. Genet. |volume=93 |issue= 1 |pages= 35–41 |year= 1994 |pmid= 7505766 |doi=
*cite journal | author=Huang LJ, Durick K, Weiner JA, "et al." |title=D-AKAP2, a novel protein kinase A anchoring protein with a putative RGS domain. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 21 |pages= 11184–9 |year= 1997 |pmid= 9326583 |doi=
*cite journal | author=Wang L, Sunahara RK, Krumins A, "et al." |title=Cloning and mitochondrial localization of full-length D-AKAP2, a protein kinase A anchoring protein. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 6 |pages= 3220–5 |year= 2001 |pmid= 11248059 |doi= 10.1073/pnas.051633398
*cite journal | author=Hamuro Y, Burns L, Canaves J, "et al." |title=Domain organization of D-AKAP2 revealed by enhanced deuterium exchange-mass spectrometry (DXMS). |journal=J. Mol. Biol. |volume=321 |issue= 4 |pages= 703–14 |year= 2002 |pmid= 12206784 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Kammerer S, Burns-Hamuro LL, Ma Y, "et al." |title=Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: a disease susceptibility polymorphism. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 7 |pages= 4066–71 |year= 2003 |pmid= 12646697 |doi= 10.1073/pnas.2628028100
*cite journal | author=Gisler SM, Pribanic S, Bacic D, "et al." |title=PDZK1: I. a major scaffolder in brush borders of proximal tubular cells. |journal=Kidney Int. |volume=64 |issue= 5 |pages= 1733–45 |year= 2004 |pmid= 14531806 |doi= 10.1046/j.1523-1755.2003.00266.x
*cite journal | author=Burns-Hamuro LL, Barraclough DM, Taylor SS |title=Identification and functional analysis of dual-specific A kinase-anchoring protein-2. |journal=Meth. Enzymol. |volume=390 |issue= |pages= 354–74 |year= 2005 |pmid= 15488188 |doi= 10.1016/S0076-6879(04)90022-5
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Tingley WG, Pawlikowska L, Zaroff JG, "et al." |title=Gene-trapped mouse embryonic stem cell-derived cardiac myocytes and human genetics implicate AKAP10 in heart rhythm regulation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 20 |pages= 8461–6 |year= 2007 |pmid= 17485678 |doi= 10.1073/pnas.0610393104

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