Sertoli cell-only syndrome

Sertoli cell-only syndrome
Sertoli cell-only syndrome
Classification and external resources
OMIM 305700 400042
DiseasesDB 31907
eMedicine med/2104
MeSH D054331

Sertoli cell-only syndrome (a.k.a. Del Castillo syndrome and germ cell aplasia [1]) is a disorder characterized by male sterility without sexual abnormality. It is the result of absent seminiferous tubules in the testes of germinal epithelium, while Sertoli cells are present.[2]



The Sertoli cell-only syndrome patients normally have normal secondary male features and have normal- or small-sized testes.


Testicular biopsy would confirm the absence of spermatozoa .


Sertoli cell only syndrome is likely multifactorial, and characterized by severely reduced or absent spermatogenesis despite the presence of both Sertoli and Leydig cells. A substantial subset of men with this uncommon syndrome have microdeletions in the Yq11 region of the Y chromosome, an area known as the AZF (azoospermia factor) region. Generally speaking, testosterone and LH levels are normal, but due to lack of inhibin, FSH levels are increased.


Sertoli cell only syndrome is like other non-obstructive azoospermia (NOA) cases are managed by sperm retrieval through testicular sperm extraction (mTESE), micro-surgical testicular sperm extraction (mTESE) , or testicular biopsy.[3] On retrieval of viable sperms this could be used in Intracytoplasmic Sperm injection ICSI

In 1979, Levin described germinal cell aplasia with focal spermatogenesis where a variable percentage of seminiferous tubules contain germ cells.[4] It is important to discriminate between both in view of ICSI.


  1. ^ Sertoli cell-only syndrome at eMedicine
  2. ^ Online Medical Dictionary.
  3. ^ Talas H, Yaman O, Aydos K (Sep 2007). "Outcome of repeated micro-surgical testicular sperm extraction in patients with non-obstructive azoospermia". Asian J Androl. 9 (5): 668–73. doi:10.1111/j.1745-7262.2007.273.x. PMID 17712484. 
  4. ^ Levin HS (September 1979). "Testicular biopsy in the study of male infertility: its current usefulness, histologic techniques, and prospects for the future". Hum. Pathol. 10 (5): 569–84. doi:10.1016/S0046-8177(79)80100-8. PMID 43278. 

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Look at other dictionaries:

  • Sertoli-cell-only syndrome — Sertoli cell only syndrome. См. синдром дель Кастильо. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • Sertoli-cell–only syndrome — congenital absence of the germinal epithelium of the testes, so that the seminiferous tubules contain only Sertoli cells and the testes are smaller than normal; there is azoospermia with elevated titers of follicle stimulating hormone and… …   Medical dictionary

  • Sertoli cell — Infobox Anatomy Name = PAGENAME Latin = GraySubject = 258 GrayPage = 1243 Caption = Germinal epithelium of the testicle. 1: basal lamina 2: spermatogonia 3: spermatocyte 1st order 4: spermatocyte 2nd order 5: spermatid 6: mature spermatid 7:… …   Wikipedia

  • syndrome — The aggregate of symptoms and signs associated with any morbid process, and constituting together the picture of the disease. SEE ALSO: disease. [G. s., a running together, tumultuous concourse; (in med.) a concurrence of symptoms, fr. syn,… …   Medical dictionary

  • Sertoli — Enrico, Italian histologist, 1842–1910. See S. cell tumor, S. cells, under cell, S. columns, under column, S. cell only syndrome, S. Leydig cell tumor, S. stromal cell tumor …   Medical dictionary

  • del Castro syndrome — del Castro syndrome. = Sertoli cell only syndrome (см.). (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

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  • Germ cell tumor — Classification and external resources Micrograph of a seminoma, a common germ cell tumor. ICD 10 C …   Wikipedia

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