True hermaphroditism

True hermaphroditism

Infobox_Disease
Name = PAGENAME


Caption =
DiseasesDB = 29664
ICD10 =
ICD9 =
ICDO =
OMIM = 235600
MedlinePlus =
eMedicineSubj = med
eMedicineTopic = 1702
MeshID = D050090

True hermaphroditism is a medical term for an intersex condition in which a person is born with both ovarian and testicular tissue.

There may be an ovary on one side and a testis on the other, but more commonly one or both gonads is an ovotestis containing both types of tissue.

It is rare for both types of gonadal tissue to function. Encountered karyotypes are 47XXY, 46XX/46XY, or 46XX/47XXY.

Although similar in some ways to mixed gonadal dysgenesis, the conditions can be distinguished histologically.cite journal |author=Kim KR, Kwon Y, Joung JY, Kim KS, Ayala AG, Ro JY |title=True hermaphroditism and mixed gonadal dysgenesis in young children: a clinicopathologic study of 10 cases |journal=Mod. Pathol. |volume=15 |issue=10 |pages=1013–9 |year=2002 |month=October |pmid=12379746 |doi=10.1097/01.MP.0000027623.23885.0D |url=http://dx.doi.org/10.1097/01.MP.0000027623.23885.0D]

Presentation

External genitalia are often ambiguous, the degree depending mainly on the amount of testosterone produced by the testicular tissue between 8 and 16 weeks of gestation.

Causes

This condition is very rare. There are several ways in which this may occur.
* It can be caused by the division of 1 ova, followed by fertilization of each haploid ova and fusion of the 2 zygotes early in development.
* Alternately, an ovum can be fertilized by two sperm followed by trisomic rescue in one or more daughter cell.

It can be associated with SRY.cite journal |author=Braun A, Kammerer S, Cleve H, Löhrs U, Schwarz HP, Kuhnle U |title=True hermaphroditism in a 46,XY individual, caused by a postzygotic somatic point mutation in the male gonadal sex-determining locus (SRY): molecular genetics and histological findings in a sporadic case |journal=Am. J. Hum. Genet. |volume=52 |issue=3 |pages=578–85 |year=1993 |month=March |pmid=8447323 |pmc=1682159 |doi= |url=]

References

ee also

* Ovotestis


Wikimedia Foundation. 2010.

Игры ⚽ Поможем решить контрольную работу

Look at other dictionaries:

  • true hermaphroditism — coexistence, in the same individual, of both ovarian and testicular tissue, caused by anomalous differentiation of the gonads; secondary sex characters of both genders may be present …   Medical dictionary

  • hermaphroditism — The presence in one individual of both ovarian and testicular tissue; i.e., true h.. SYN: hermaphrodism. adrenal h. altered appearance of the genitalia due to disorders of adrenocortical function, most often female virilization; not an example of …   Medical dictionary

  • true hermaphrodite — an individual with true hermaphroditism, having both testicular and ovarian tissue. Called also true intersex …   Medical dictionary

  • hermaphroditism — /herr maf reuh duy tiz euhm/, n. the condition of being a hermaphrodite. Also, hermaphrodism /herr maf reuh diz euhm/. [1800 10; HERMAPHRODITE + ISM] * * * Condition of having both male and female reproductive organs (see reproductive system). It …   Universalium

  • Intersexuality — is the state of a living thing of a gonochoristic species whose sex chromosomes, genitalia, and/or secondary sex characteristics are determined to be neither exclusively male nor female. An organism with intersex may have biological… …   Wikipedia

  • Hermaphrodite — For other uses, see Hermaphrodite (disambiguation). Mating Helix aspersa (garden snails). In biology, a hermaphrodite is an organism that has reproductive organs normally associated with both male and female sexes.[1] Many taxonomic groups of an …   Wikipedia

  • reproductive system, animal — Introduction       any of the organ systems by which animals reproduce.       The role of reproduction is to provide for the continued existence of a species; it is the process by which living organisms duplicate themselves. Animals compete with… …   Universalium

  • Androgen insensitivity syndrome — Classification and external resources AIS results when the function of the androgen receptor (AR) is impaired. The AR protein (pictured) mediates the effects of androgens in the human body. ICD 10 E …   Wikipedia

  • Pseudohermaphroditism — Classification and external resources ICD 10 Q56.1 Q56.3 ICD 9 …   Wikipedia

  • List of sexology topics — This is a list of topics related to sexology, human sexuality and marriage customs, and related topics such as human sexual anatomy, reproductive biology, andrology, gynaecology, obstetrics and, where relevant, anthropology. Note that this list… …   Wikipedia

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”