Digoxin Immune Fab

Digoxin Immune Fab

Systematic (IUPAC) name
Anti-digoxin antibody fragment
Clinical data
AHFS/Drugs.com	Consumer Drug Information
Pregnancy cat.	C(US)
Legal status	?
Routes	IV infusion, injection
Pharmacokinetic data
Half-life	15 hours for DigiFab, 23 hours for Digibind
Excretion	Renal
Identifiers
ATC code	V03AB24
DrugBank	BTD00027
ChEMBL	CHEMBL1201588 N
Chemical data
Formula	C6394H9908N1698O2011S58
Mol. mass	144602.257 g/mol
N(what is this?)  Immune Fab (verify)

Digoxin Immune Fab (Ovine) is the generic name for an antidote for overdose of digitalis.^[1] It is made from immunoglobulin fragments from sheep who have already been immunized with a digoxin derivative, digoxindicarboxymethoxylamine (DDMA). Its brand names include Digibind and DigiFab, with the former manufactured by GlaxoSmithKline and the latter manufactured by BTG plc.

Digoxin immune Fab used to treat digoxin toxicity

Pharmacology

It works by binding to the digoxin, rendering them unable to bind to their action sites on target cells. The complexes accumulate in the blood and are expelled by the kidney.

Contraindications

Although no contraindications have been noted, the patient must be closely monitored for anaphylactic shock, and anyone allergic to sheep protein, papain, bromelain, or papaya extracts (papain is used to cleave the antibody into Fab and Fc fragments) should not use Digoxin Immune Fab (Ovine). Because it is relatively new, no drug interaction studies have been performed yet.

References

1. ^ DiDomenico RJ, Walton SM, Sanoski CA, Bauman JL (2000). "Analysis of the use of digoxin immune fab for the treatment of non-life-threatening digoxin toxicity". J. Cardiovasc. Pharmacol. Ther. 5 (2): 77–85. doi:10.1053/XV.2000.5590. PMID 11150387. 

External links

• Drug information online
• Digibind description
• DigiFab

This pharmacology-related article is a stub. You can help Wikipedia by expanding it.v · Categories: GlaxoSmithKline Pharmacology stubs Wikimedia Foundation. 2010. Игры ⚽ Поможем решить контрольную работу Armenian American literature Djibril Bassolé Look at other dictionaries: digoxin immune Fab (ovine) — a preparation of antigen binding fragments derived from specific antidigoxin antibodies produced in sheep that have been immunized with digoxin coupled as a hapten to human serum albumin, used as an antidote to life threatening digoxin and… …   Medical dictionary digoxin immune Fab (ovine) — see under Fab …   Medical dictionary Digoxin toxicity — Classification and external resources Digitalis purpurea drawings by Franz Köhler ICD 10 T …   Wikipedia Antidote — For other uses, see Antidote (disambiguation). An antidote is a substance which can counteract a form of poisoning.[1] The term ultimately derives from the Greek αντιδιδοναι antididonai, given against . The antidotes for some particular toxins… …   Wikipedia Glutathione — Glutathione[1] …   Wikipedia Nerium — Oleander redirects here. For other uses, see Oleander (disambiguation). Nerium Nerium oleander in flower Scientific classification …   Wikipedia Methionine — Methionine …   Wikipedia Acetylcysteine — Systematic (IUPAC) name …   Wikipedia Diazepam — Systematic (IUPAC) name 7 chlo …   Wikipedia Amyl nitrite — Not to be confused with amyl nitrate. Amyl nitrite …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”