Syrup of ipecac

Syrup of ipecac

Syrup of ipecac commonly referred to as simply Ipecac is derived from the dried rhizome and roots of the ipecacuanha plant and is a well-known emetic (substance used to induce vomiting).

Mechanism of action

The actions of Ipecac are mainly those of its major alkaloids, emetine (methylcephalin) and cephalin. They both act locally by irritating the gastric mucosa and centrally by stimulating the medullary chemoreceptor trigger zone to induce vomiting. Syrup of ipecac is still used to induce vomiting.


Ipecac was used in cough mixtures as an expectorant and from the 18th until the early 20th century. Ipecac and opium were used to produce Dover's powder, which was used in syrup form.

Pediatricians once recommended Ipecac be kept in the home as a ready emetic for use in cases of accidental poisoning. [citation|author = Committee on Injury, Violence, and Poison Prevention|title = Office-Based Counseling for Injury Prevention|journal = Pediatrics|volume = 94|number = 4|pages = 566–567|year = 1994|url =] Current guidelines from the American Academy of Pediatrics, however, strongly advise against this and in fact recommend the disposal of any syrup of Ipecac present in the home. [citation|author = Committee on Injury, Violence, and Poison Prevention|title = Poison Treatment in the Home|journal = Pediatrics|volume = 112|number = 5|pages = 1182–1185|doi = 10.1542/peds.112.5.1182|year = 2003|url =|pmid = 14595067] Many toxicological associations have also issued position papers recommending against its use as a first-line treatment for most ingested poisons. [cite journal|last1 = Manoguerra|first1 = A S|last2 = Krenzelok|first2 = E P|last3 = McGuigan|first3 = M|last4 = Lheureux|first4 = P|year = 2004|title = AACT/EAPCCT position paper: ipecac syrup|journal = Clinical Toxicology|volume = 42|pages = 133–43|doi = 10.1081/CLT-120037421|author = Toxicology, American Academy of Clinical] , because:
# There has been no evidence that syrup of Ipecac actually helps improve the outcome in cases of poisoning.
# Administering syrup of Ipecac can delay administering more effective treatments, such as activated charcoal and/or antidotes.
# The effects of the Ipecac itself can be mistaken for the effects of the poisoning.
# Accidental overdose of Ipecac can result when administered in the home. [citation|title = Gastric decontamination—a view for the millennium|last = Bateman|first = D N|journal = British Medical Journal|volume = 16|number = 2|pages = 84|year = 1999|publisher = BAEM|url =|pmid = 10191436]

A 2005 review by an HRSA-funded scientific panel concluded that vomiting alone does not reliably remove poisons from the stomach. The study suggested that indications for use of Ipecac syrup were rare and patients should be treated by more effective and safer means. Additionally, Ipecac’s potential side effects, such as lethargy, can be confused with the poison’s effects, complicating diagnosis. Ipecac may also delay the administration or reduce the effectiveness of other treatments such as activated charcoal, whole bowel irrigation, or oral antidotes. [citation|title = Guideline on the Use of Ipecac Syrup in the Out-of-Hospital Management of Ingested Poisons|last1 = Manoguerra|first1 = A S|last2 = Cobaugh|first2 = D J|journal = Clinical Toxicology|volume = 43|number = 1|pages = 1–10|year = 2005|url =|doi = 10.1081/CLT-200046735|author = Manoguerra, Anthony]


Ipecac has been used by individuals with bulimia nervosa as a means to achieve weight loss through induced defensive vomiting. Repeated abuse is believed to cause damage to the heart, which can ultimately result in the user's death. [citation|last = Silber|first = T J|year = 2005|title = Ipecac syrup abuse, morbidity, and mortality: Isn’t it time to repeal its over-the-counter status?|journal = Journal of Adolescent Health|volume = 37|issue = 3|pages = 256–260|url =|accessdate = 2008-05-02|doi = 10.1016/j.jadohealth.2004.08.022]

See also



External links

* [ MedlinePlus Drug Information]
* [;112/5/1182 AAP policy on Poison Treatment in the Home]
* [ Chemical Poisoning and Syrup of Ipecac]

Wikimedia Foundation. 2010.

Игры ⚽ Нужно сделать НИР?

Look at other dictionaries:

  • syrup of ipecac — n IPECAC SYRUP …   Medical dictionary

  • syrup of ipecac — Pharm. See ipecac syrup. * * * …   Universalium

  • syrup of ipecac — Pharm. See ipecac syrup …   Useful english dictionary

  • syrup of ipecac — noun liquid medicine made from a flowering plant, Psychotria ipecacuanha, used as an emetic; ipecac …   Wiktionary

  • ipecac syrup — n an emetic and expectorant liquid preparation that is widely used to induce vomiting in accidental poisoning, that contains the alkaloids emetine and cephaeline, and that is prepared by extracting the ether soluble alkaloids from powdered ipecac …   Medical dictionary

  • Ipecac — may refer to:* Syrup of ipecac, an emetic substance, used to induce vomiting * Ipecac Recordings, an independent record label founded by Mike Patton and Greg Werckman …   Wikipedia

  • Ipecac Recordings — Infobox record label name = Ipecac Recordings image bg = white parent = founded = April 1, 1999 founder = Mike Patton Greg Werckman defunct = distributor = Southern Records genre = Various country = United States location = Orinda, California url …   Wikipedia

  • ipecac syrup — Pharm. a preparation containing ipecac in a syrupy medium, used as an emetic. Also called syrup of ipecac. * * * …   Universalium

  • ipecac syrup — Pharm. a preparation containing ipecac in a syrupy medium, used as an emetic. Also called syrup of ipecac …   Useful english dictionary

  • Ipecac — A naturally occurring substance with multiple properties including the ability to cause vomiting (emesis). Ipecac is derived from dried roots of a bush called Uragoga ipecacuanha that is native to Brazil. In the past, a sizable proportion of… …   Medical dictionary

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”