Benzethonium chloride

Benzethonium chloride
Benzethonium chloride
CAS number 121-54-0 YesY
PubChem 8478
ChemSpider 8165 YesY
UNII PH41D05744 YesY
EC number 204-479-9
UN number 2923
KEGG D01140 YesY
MeSH Benzethonium
RTECS number BO7175000
ATC code D08AJ08,R02AA09
Beilstein Reference 3898548
Jmol-3D images Image 1
Image 2
Molecular formula C27H42ClNO2
Molar mass 448.08 g mol−1
Exact mass 447.290407300 g mol-1
Melting point

163 °C, 436 K, 325 °F

Solubility in water 40 g dm-3 (at 20 °C)
Routes of
Legal status


GHS pictograms The corrosion pictogram in the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) The skull-and-crossbones pictogram in the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) The environment pictogram in the Globally Harmonized System of Classification and Labelling of Chemicals (GHS)
GHS signal word Danger
GHS hazard statements H301, H314, H400
GHS precautionary statements P273, P280, P305+351+338, P310
EU classification Harmful Xn
R-phrases R22 R37/38 R41
S-phrases S26 S36/39
 N chloride (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Benzethonium chloride is a synthetic quaternary ammonium salt. This compound is an odorless white solid; soluble in water. It has surfactant, antiseptic, and anti-infective properties, and it is used as a topical antimicrobial agent in first aid antiseptics. It is also found in cosmetics and toiletries such as mouthwashes, anti-itch ointments, and antibacterial moist towelettes. Benzethonium chloride is also used in the food industry as a hard surface disinfectant.[1]

Benzethonium chloride exhibits a broad spectrum of microbiocidal activity against bacteria, fungi, mold and viruses. Independent testing shows that benzethonium chloride is highly effective against such pathogens as methicillin-resistant Staphylococcus aureus, Salmonella, Escherichia coli, Clostridium difficile, hepatitis B virus, hepatitis C virus, herpes simplex virus (HSV), human immunodeficiency virus (HIV), respiratory syncytial virus (RSV), and norovirus.

The US Food and Drug Administration (FDA) specifies that the safe and effective concentrations for benzethonium chloride are 0.1-0.2% in first aid products.[2] Aqueous solutions of benzethonium chloride are not absorbed through the skin. It is not approved in the US and Europe for use as a food additive. In Switzerland it is classified as a class-2 poison.[citation needed]

In addition to its highly effective antimicrobial activity, benzethonium chloride contains a positively charged nitrogen atom covalently bonded to four carbon atoms. This positive charge attracts it to the skin and hair. This contributes to a soft, powdery afterfeel on the skin and hair, as well as long-lasting persistent activity against microorganisms.

It is available under trade names Salanine, BZT, Diapp, Quatrachlor, Polymine D, Phemithyn, Antiseptol, Disilyn, Phermerol, and others.[3]


  1. ^ Record in the Household Products Database of NLM
  2. ^ Tentative final monograph (21CFR333)[clarification needed]
  3. ^ MSDS

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  • benzethonium chloride — /ben zeuh thoh nee euhm/, Chem. a colorless, water soluble, crystalline solid, ammonium chloride derivative, (C27H42O2N)Cl·H2O, used chiefly as an antiseptic. [BENZ(YL) + (M)ETH(YL) + (AMM)ONIUM] * * * …   Universalium

  • benzethonium chloride — noun A synthetic quaternary ammonium salt with surfactant, antiseptic, and anti infective properties …   Wiktionary

  • benzethonium chloride — A synthetic quaternary ammonium compound, one of the cationic class of detergents; germicidal and bacteriostatic. * * * ben·ze·tho·ni·um chlo·ride (ben″zə thoґne əm) [USP] a synthetic quaternary ammonium compound with …   Medical dictionary

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  • ATC code D08 — ATC codes D Dermatologicals D01 Antifungals for dermatological use D02 Emollients and protectives D03 Preparations for treatment of wounds and ulcers D04 Antipruritics, including antihistamines, anesthetics, etc. D05 Antipsoriatics D06 Antibiot …   Wikipedia

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