- Benzethonium chloride
Benzethonium chloride Identifiers CAS number PubChem ChemSpider UNII EC number UN number 2923 KEGG MeSH ChEMBL RTECS number BO7175000 ATC code D08,R02 Beilstein Reference 3898548 Jmol-3D images Image 1
Properties Molecular formula C27H42ClNO2 Molar mass 448.08 g mol−1 Exact mass 447.290407300 g mol-1 Melting point
163 °C, 436 K, 325 °F
Solubility in water 40 g dm-3 (at 20 °C) Pharmacology Routes of
topical Legal status
Hazards GHS pictograms GHS signal word Danger GHS hazard statements , , GHS precautionary statements , , , EU classification Xn R-phrases S-phrases (what is: /?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Benzethonium chloride is a synthetic quaternary ammonium salt. This compound is an odorless white solid; soluble in water. It has surfactant, antiseptic, and anti-infective properties, and it is used as a topical antimicrobial agent in first aid antiseptics. It is also found in cosmetics and toiletries such as mouthwashes, anti-itch ointments, and antibacterial moist towelettes. Benzethonium chloride is also used in the food industry as a hard surface disinfectant.
Benzethonium chloride exhibits a broad spectrum of microbiocidal activity against bacteria, fungi, mold and viruses. Independent testing shows that benzethonium chloride is highly effective against such pathogens as methicillin-resistant Staphylococcus aureus, Salmonella, Escherichia coli, Clostridium difficile, hepatitis B virus, hepatitis C virus, herpes simplex virus (HSV), human immunodeficiency virus (HIV), respiratory syncytial virus (RSV), and norovirus.
The US Food and Drug Administration (FDA) specifies that the safe and effective concentrations for benzethonium chloride are 0.1-0.2% in first aid products. Aqueous solutions of benzethonium chloride are not absorbed through the skin. It is not approved in the US and Europe for use as a food additive. In Switzerland it is classified as a class-2 poison.
In addition to its highly effective antimicrobial activity, benzethonium chloride contains a positively charged nitrogen atom covalently bonded to four carbon atoms. This positive charge attracts it to the skin and hair. This contributes to a soft, powdery afterfeel on the skin and hair, as well as long-lasting persistent activity against microorganisms.
It is available under trade names Salanine, BZT, Diapp, Quatrachlor, Polymine D, Phemithyn, Antiseptol, Disilyn, Phermerol, and others.
Antiseptics and disinfectants (D08) Acridine derivatives Biguanides and amidines Phenol and derivatives Nitrofuran derivativesNitrofurazone Iodine products Quinoline derivatives Quaternary ammonium compounds Mercurial products Silver compounds Alcohols Other Throat preparations (R02) Antiseptics Antibiotics Local anesthetics Other
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