Nateglinide

Nateglinide: Nateglinide

Systematic (IUPAC) name

3-phenyl-2-[(4-propan-2-ylcyclohexanecarbonyl)amino]propanoic acid

Clinical data

Trade names Starlix

AHFS/Drugs.com monograph

MedlinePlus a699057

Licence data EMA:Link, US FDA:link

Pregnancy cat. ?

Legal status POM (UK) ℞-only (US)

Routes Oral

Pharmacokinetic data

Protein binding 98%

Half-life 1.5 hours

Identifiers

CAS number 105816-04-4^Y

ATC code A10BX03

PubChem CID 60026

DrugBank APRD00593

ChemSpider 10482084^Y

UNII 41X3PWK4O2^Y

KEGG D01111^N

ChEMBL CHEMBL783^Y

Chemical data

Formula C₁₉H₂₇N O₃

Mol. mass 317.423 g/mol

SMILES eMolecules & PubChem

InChI

InChI=1S/C19H27NO3/c1-13(2)15-8-10-16(11-9-15)18(21)20-17(19(22)23)12-14-6-4-3-5-7-14/h3-7,13,15-17H,8-12H2,1-2H3,(H,20,21)(H,22,23)/t15-,16-,17-/m1/s1^Y
Key:OELFLUMRDSZNSF-BRWVUGGUSA-N^Y

N(what is this?) (verify)

Nateglinide (INN, trade name Starlix) is a drug for the treatment of type 2 diabetes. Nateglinide was developed by Ajinomoto, a Japanese company and sold by the Swiss pharmaceutical company Novartis.

Nateglinide belongs to the meglitinide class of blood glucose-lowering drugs.

Pharmacology

Nateglinide lowers blood glucose by stimulating the release of insulin from the pancreas. It achieves this by closing ATP-dependent potassium channels in the membrane of the β cells. This depolarizes the β cells and causes voltage-gated calcium channels to open. The resulting calcium influx induces fusion of insulin-containing vesicles with the cell membrane, and insulin secretion occurs.

Dosage

Nateglinide is delivered in 60mg & 120mg tablet form.

External links

Starlix - website of the manufacturer.

How Nateglinide Works - website of the manufacturer.

v · d · eOral anti-diabetic drugs and Insulin analogs (A10)

Insulin

Sensitizers

Biguanides

Metformin^# • Buformin^‡ • Phenformin^‡

TZDs (PPAR)

Pioglitazone • Rivoglitazone^† • Rosiglitazone • Troglitazone^‡

Dual PPAR agonist

Aleglitazar^† • Muraglitazar^§ • Tesaglitazar^§

Secretagogues

K+ ATP

Sulfonylureas

1st generation: Acetohexamide • Carbutamide • Chlorpropamide • Tolbutamide • Tolazamide
2nd generation: Glibenclamide (Glyburide)^# • Glipizide • Gliquidone • Glyclopyramide • Glimepiride • Gliclazide •

Meglitinides/"glinides"

Nateglinide • Repaglinide • Mitiglinide

GLP-1 analogs

Exenatide • Liraglutide • Taspoglutide^† • Albiglutide^† • Lixisenatide

DPP-4 inhibitors

Alogliptin^† • Linagliptin • Saxagliptin • Sitagliptin • Vildagliptin

Analogs/other insulins

fast-acting (Insulin lispro • Insulin aspart • Insulin glulisine) • short-acting (Regular insulin) • long-acting (Insulin glargine • Insulin detemir • NPH insulin) • ultra-long-acting (Insulin degludec^†) • inhalable Exubera^‡

Other

Alpha-glucosidase inhibitors

Acarbose • Miglitol • Voglibose

Amylin analog

Pramlintide

SGLT2 inhibitors

Canagliflozin^† • Dapagliflozin^† • Remogliflozin^§ • Sergliflozin^§

Other

Benfluorex^‡ • Tolrestat^‡

^#WHO-EM. ^‡Withdrawn from market. Clinical trials: ^†Phase III. ^§Never to phase III

M: END

anat/phys/devp/horm

noco(d)/cong/tumr, sysi/epon

proc, drug (A10/H1/H2/H3/H5)

Categories:
Meglitinides
Amides

Nateglinide

Systematic (IUPAC) name
3-phenyl-2-[(4-propan-2-ylcyclohexanecarbonyl)amino]propanoic acid
Clinical data
Trade names	Starlix
AHFS/Drugs.com	monograph
MedlinePlus	a699057
Licence data	EMA:Link, US FDA:link
Pregnancy cat.	?
Legal status	POM (UK) ℞-only (US)
Routes	Oral
Pharmacokinetic data
Protein binding	98%
Half-life	1.5 hours
Identifiers
CAS number	105816-04-4^Y
ATC code	A10BX03
PubChem	CID 60026
DrugBank	APRD00593
ChemSpider	10482084^Y
UNII	41X3PWK4O2^Y
KEGG	D01111^N
ChEMBL	CHEMBL783^Y
Chemical data
Formula	C₁₉H₂₇N O₃
Mol. mass	317.423 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C19H27NO3/c1-13(2)15-8-10-16(11-9-15)18(21)20-17(19(22)23)12-14-6-4-3-5-7-14/h3-7,13,15-17H,8-12H2,1-2H3,(H,20,21)(H,22,23)/t15-,16-,17-/m1/s1^Y Key:OELFLUMRDSZNSF-BRWVUGGUSA-N^Y
N(what is this?) (verify)

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Look at other dictionaries:

nateglinide — noun A meglitinide drug for the treatment of type II diabetes that lowers blood glucose by stimulating the release of insulin from the pancreas … Wiktionary
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nateglinide — n.; see meglitinides … The new mediacal dictionary
Meglitinide — Meglitinides, aka Glinides [1], are a class of drugs used treat diabetes type 2. They bind to an ATP dependent K+ (KATP) channel on the cell membrane of pancreatic beta cells in a similar manner to sulfonylureas but at a separate binding site.… … Wikipedia
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Glimepiride — Systematic (IUPAC) name 3 ethyl 4 methyl N (4 [N ((1r,4r) 4 methylcyclohexylcarbamoyl)sulfamoyl]phenethyl) 2 oxo 2,5 dihydro 1H pyrrole 1 carboxamide Clinical … Wikipedia
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Nateglinide

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Wikipedia

Nateglinide

Pharmacology

Dosage

External links

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