- Acetohexamide
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Not to be confused with acetazolamide.
Acetohexamide 
Systematic (IUPAC) name 4-acetyl-N-(cyclohexylcarbamoyl)benzenesulfonamide Clinical data Trade names Dymelor AHFS/Drugs.com Micromedex Detailed Consumer Information MedlinePlus a602021 Pregnancy cat. ? Legal status ? Pharmacokinetic data Protein binding 90% Identifiers CAS number 968-81-0 
ATC code A10BB31 PubChem CID 1989 DrugBank APRD00773 ChemSpider 1912 UNII QGC8W08I6I KEGG D00219 ChEBI CHEBI:28052 ChEMBL CHEMBL1589 Chemical data Formula C15H20N2O4S Mol. mass 324.395 g/mol SMILES eMolecules & PubChem - InChI=1S/C15H20N2O4S/c1-11(18)12-7-9-14(10-8-12)22(20,21)17-15(19)16-13-5-3-2-4-6-13/h7-10,13H,2-6H2,1H3,(H2,16,17,19)
Key:VGZSUPCWNCWDAN-UHFFFAOYSA-N
(what is this?) (verify)Acetohexamide (trade name Dymelor) is a first-generation sulfonylurea medication used to treat diabetes mellitus type 2, particularly in people whose diabetes cannot be controlled by diet alone.
Mechanism of action
Acetohexamide lowers blood sugar by stimulating the pancreas to secrete insulin and helping the body use insulin efficiently.[1] The pancreas must produce insulin for this medication to work. For this reason, acetohexamide is not used to treat diabetes mellitus type 1.
metabolic reduction of acetohexamide into the active hypoglycemic metabolite S-(-)-hydroxyhexamide is carried out by cytochromes
Risks
Oral hypoglycemic drugs, including acetohexamide, have been associated with increased cardiovascular mortality. Talk to your doctor about the possible risks, benefits, and alternatives of using this drug for your condition.[2]
References
- ^ [1] - Metformin Side Effects
- ^ Medline Plus - Acetohexamide
Oral anti-diabetic drugs and Insulin analogs (A10) Insulin K+ ATP1st generation: Acetohexamide • Carbutamide • Chlorpropamide • Tolbutamide • Tolazamide
2nd generation: Glibenclamide (Glyburide)# • Glipizide • Gliquidone • Glyclopyramide • Glimepiride • Gliclazide •Meglitinides/"glinides"GLP-1 analogsExenatide • Liraglutide • Taspoglutide† • Albiglutide† • LixisenatideAnalogs/other insulinsfast-acting (Insulin lispro • Insulin aspart • Insulin glulisine) • short-acting (Regular insulin) • long-acting (Insulin glargine • Insulin detemir • NPH insulin) • ultra-long-acting (Insulin degludec†) • inhalable Exubera‡Other Amylin analogSGLT2 inhibitorsCanagliflozin† • Dapagliflozin† • Remogliflozin§ • Sergliflozin§OtherBenfluorex‡ • Tolrestat‡
This drug article relating to the gastrointestinal system is a stub. You can help Wikipedia by expanding it. - InChI=1S/C15H20N2O4S/c1-11(18)12-7-9-14(10-8-12)22(20,21)17-15(19)16-13-5-3-2-4-6-13/h7-10,13H,2-6H2,1H3,(H2,16,17,19)
