Insulin glargine

Insulin glargine

IUPAC_name=Recombinant human insulin

C=267 | H=408 | N=72 | O=77 | S=6
molecular_weight=6063 g/mol
routes_of_administration= Subcutaneous

Insulin glargine, marketed by Sanofi-Aventis under the name Lantus, is a long-acting basal insulin analogue, usually given once or twice daily to help control the blood sugar level of those with diabetes. Its theoretical advantage is that it has a duration of action up to 24 hours, with a "less peaked" profile than NPH. Thus, it more closely resembles the basal insulin secretion of the normal pancreatic beta cells. In type 2 diabetes and in combination with a short acting sulfonylurea (drugs which stimulate the pancreas to make more insulin), it can offer moderate control of serum glucose levels. In the absence of endogenous insulin (Type 1 diabetes or depleted type 2), Lantus needs the support of a fast acting insulin taken with food to reduce the effect of prandially derived glucose. It is post-prandial glucose elevation which more significantly affects HbA1c and thus determines the progression of the long-term complications of diabetes mellitus.The peakless profile of Lantus also enables the dose to be relatively higher than standard NPH insulin. Because standard NPH is normally administered at night, its peak of action tends to coincide with the lower serum glucose levels associated with nocturnal metabolism. This can induce nocturnal hypoglycaemia. Lantus offers the benefit of a more consistent pharmacological dynamic without nocturnal hypoglycaemia. The result of this is a patient who feels more confident and more comfortable with a lower pre-bed and pre-breakfast capillary glucose level.

Lantus is formulated at an acidic pH 4, where it is completely water soluble. After subcutaneous injection of the acidic solute ( which can cause discomfort and a stinging sensation and can be mitigated with the use of the I-port ), the body, at pH 7, slowly neutralizes the solution, causing insulin microcrystals to gradually precipitate from the insulin glargine solution, which then release insulin in bioloigically active form. This gradual process ensures that small amounts of Lantus are released into the body continuously, giving an almost peakless profile. Significant weight gain is seen in many patients using Lantus.

Mechanism of Action

Insulin glargine have subsitution of glycine for asparagine at A21 and two arginines added to the carboxy terminal of B chain. This allows insulin glargine to form a precipitate (hexamer) when injected subcutaneously into the patient. It can achieve a peakless level for at least 24 hours.

External links

* [ Insulin glargine] - MedlinePlus
* [ Lantus website] (Sanofi-Aventis)

Wikimedia Foundation. 2010.

Игры ⚽ Нужно сделать НИР?

Look at other dictionaries:

  • insulin glargine — an insulin analogue that differs from human insulin in that the asparagine at position A21 is replaced by glycine and two arginines are added to the C terminus of the B chain; administered subcutaneously for once daily insulin replacement therapy …   Medical dictionary

  • Insulin glargin — Masse/Länge Primärstruktur 51 Aminosäuren, 6,06 kDa …   Deutsch Wikipedia

  • Insulin aspart — Clinical data AHFS/ …   Wikipedia

  • Insulin detemir — Clinical data AHFS/ monograph MedlinePlus …   Wikipedia

  • Insulin analog — An insulin analog is an altered form of insulin, different from any occurring in nature, but still available to the human body for performing the same action as human insulin in terms of glycemic control. Through genetic engineering of the… …   Wikipedia

  • Insulin — This article is about the insulin protein. For uses of insulin in treating diabetes, see insulin therapy. Not to be confused with inulin. Insulin Computer generated image of six insulin molecules assembled in a hexamer, highlighting the threefold …   Wikipedia

  • insulin analogues — a group of synthetic human insulins with specific alterations in their amino acid sequences designed to modify their rate of absorption from the injection site (subcutaneous tissue). Some are absorbed much more rapidly and have a shorter duration …   The new mediacal dictionary

  • NPH insulin — (or neutral protamine Hagedorn) (also known as Humulin N, Novolin N, Novolin NPH, NPH Lletin II, and isophane insulin), is an intermediate acting insulin given to help control the blood sugar level of those with diabetes. NPH was created in 1936… …   Wikipedia

  • Diabetes in cats — Diabetes mellitus strikes 1 in 400 cats, though recent veterinary studies[1][2][3] note that it is becoming more common lately in cats. Symptoms in cats are similar to those in humans. Diabetes in cats occurs less frequently than in dogs.[4] 80… …   Wikipedia

  • Diabetes in cats and dogs — Diabetes mellitus strikes 1 in 400 cats and a similar number of dogs, though recent veterinary studies [ [ Fat Cats Facing Diabetes Epidemic, The Guardian, August 7 2007] ] [Journal of Feline… …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”