Clofibrate

Clofibrate

Systematic (IUPAC) name
ethyl 2-(4-chlorophenoxy)-2-methylpropanoate
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pregnancy cat.	B1(AU) C(US)
Legal status	℞-only (US)
Routes	Oral
Pharmacokinetic data
Protein binding	Variable, 92–97% at therapeutic concentrations
Metabolism	Hydrolyzed to clofibric acid; hepatic glucuronidation
Half-life	Highly variable; average 18–22 hours. Prolonged in renal failure
Excretion	Renal, 95 to 99%
Identifiers
CAS number	637-07-0
ATC code	C10AB01
PubChem	CID 2796
DrugBank	APRD00879
ChemSpider	2694 Y
UNII	HPN91K7FU3 Y
KEGG	D00279 Y
ChEBI	CHEBI:3750 Y
ChEMBL	CHEMBL565 Y
Chemical data
Formula	C12H15ClO3
Mol. mass	242.698 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C12H15ClO3/c1-4-15-11(14)12(2,3)16-10-7-5-9(13)6-8-10/h5-8H,4H2,1-3H3 Y Key:KNHUKKLJHYUCFP-UHFFFAOYSA-N Y
Physical data
Boiling point	148 °C (298 °F)
Y(what is this?)  (verify)

Clofibrate (tradename Atromid-S) is a fibrate. It is a lipid lowering agent used for controlling the high cholesterol and triacylglyceride level in the blood. It increases lipoprotein lipase activity to promote the conversion of VLDL to LDL, and hence reduce the level of VLDL. It is proved that it can increase the level of HDL as well.

It can induce SIADH, syndrome of inappropriate secretion of antidiuretic hormone ADH (vasopressin).

The World Health Organization Cooperative Trial on Primary Prevention of Ischaemic Heart Disease using clofibrate to lower serum cholesterol observed that there was excess mortality in the clofibrate-treated group despite successful cholesterol lowering (47% more deaths during treatment with clofibrate and 5% after treatment with clofibrate) than the non-treated high cholesterol group. These deaths were due to a wide variety of causes other than heart disease, and remain "unexplained".^[1]

References

1. ^ "WHO cooperative trial on primary prevention of ischaemic heart disease with clofibrate to lower serum cholesterol: final mortality follow-up. Report of the Committee of Principal Investigators". Lancet 2 (8403): 600–4. September 1984. PMID 6147641. 

This drug article relating to the cardiovascular system is a stub. You can help Wikipedia by expanding it.v · Categories: Fibrates Prodrugs Organochlorides Phenol ethers Cardiovascular system drug stubs Wikimedia Foundation. 2010. Игры ⚽ Нужно сделать НИР? Aluminium clofibrate 2002 AFL Womens National Championships Look at other dictionaries: Clofibrate — Général Nom IUPAC 2 (4 chlorophénoxy) 2 méthylpropanoate d éthyle No CAS …   Wikipédia en Français clofibrate — ● clofibrate nom masculin Médicament agissant sur la synthèse des lipoprotéines, dont il abaisse la teneur dans le sang. (Il diminue le taux de cholestérol, des triglycérides et des lipides totaux sanguins.) …   Encyclopédie Universelle clofibrate — [klō fī′brāt΄, klōfib′rāt΄] n. a drug, C12H15ClO3, taken to reduce the level of lipids, esp. cholesterol, in the blood …   English World dictionary clofibrate — noun a drug (trade name Atromid S) that reduces lipids in the blood serum; used to treat some cardiovascular diseases • Syn: ↑Atromid S • Usage Domain: ↑trade name (for: ↑Atromid S) • Hypernyms: ↑medicine …   Useful english dictionary clofibrate — noun Etymology: perhaps from chlor + fibr + 1 ate Date: 1964 a compound C12H15ClO3 used especially to lower abnormally high concentrations of fats and cholesterol in the blood …   New Collegiate Dictionary clofibrate — /kloh fuy brayt, fib rayt/, n. Pharm. a substance, C12H15ClO3, used principally to reduce elevated plasma triglyceride and cholesterol levels. [1960 65; clofibr(ic acid) (perh. C(H)LO(RO) 2 + FIBR + IC) + ATE2] * * * …   Universalium clofibrate — noun A synthetic fibrate, ethyl 2 (4 chlorophenoxy) 2 methylpropanoate …   Wiktionary clofibrate — An antilipemic agent that reduces plasma levels of cholesterol, triglycerides, and uric acid; used in the treatment of hypercholesterolemia and atherosclerosis. * * * clo·fi·brate klō fīb .rāt, fib n a synthetic drug C12H15ClO3 used esp. to lower …   Medical dictionary clofibrate — clo·fi·brate …   English syllables Aluminium clofibrate — drugbox IUPAC name = CAS number = 24818 79 9 ATC prefix = C10 ATC suffix = AB03 PubChem = 6328223 DrugBank = C=20|H=24|Al=1|Cl=2|O=7 molecular weight = 474.287 g/mol bioavailability = protein bound = metabolism = Hydrolyzed to clofibric acid and… …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”