- Clofibrate
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Clofibrate Systematic (IUPAC) name ethyl 2-(4-chlorophenoxy)-2-methylpropanoate Clinical data AHFS/Drugs.com Micromedex Detailed Consumer Information Pregnancy cat. B1(AU) C(US) Legal status ℞-only (US) Routes Oral Pharmacokinetic data Protein binding Variable, 92–97% at therapeutic concentrations Metabolism Hydrolyzed to clofibric acid; hepatic glucuronidation Half-life Highly variable; average 18–22 hours. Prolonged in renal failure Excretion Renal, 95 to 99% Identifiers CAS number 637-07-0 ATC code C10AB01 PubChem CID 2796 DrugBank APRD00879 ChemSpider 2694 UNII HPN91K7FU3 KEGG D00279 ChEBI CHEBI:3750 ChEMBL CHEMBL565 Chemical data Formula C12H15ClO3 Mol. mass 242.698 g/mol SMILES eMolecules & PubChem Physical data Boiling point 148 °C (298 °F) (what is this?) (verify) Clofibrate (tradename Atromid-S) is a fibrate. It is a lipid lowering agent used for controlling the high cholesterol and triacylglyceride level in the blood. It increases lipoprotein lipase activity to promote the conversion of VLDL to LDL, and hence reduce the level of VLDL. It is proved that it can increase the level of HDL as well.
It can induce SIADH, syndrome of inappropriate secretion of antidiuretic hormone ADH (vasopressin).
The World Health Organization Cooperative Trial on Primary Prevention of Ischaemic Heart Disease using clofibrate to lower serum cholesterol observed that there was excess mortality in the clofibrate-treated group despite successful cholesterol lowering (47% more deaths during treatment with clofibrate and 5% after treatment with clofibrate) than the non-treated high cholesterol group. These deaths were due to a wide variety of causes other than heart disease, and remain "unexplained".[1]
References
- ^ "WHO cooperative trial on primary prevention of ischaemic heart disease with clofibrate to lower serum cholesterol: final mortality follow-up. Report of the Committee of Principal Investigators". Lancet 2 (8403): 600–4. September 1984. PMID 6147641.
Lipid modifying agents (C10) GI tract Ezetimibe • SCH-48461Liver Simvastatin# • Atorvastatin • Fluvastatin • Lovastatin • Mevastatin • Pitavastatin • Pravastatin • Rosuvastatin • Cerivastatin‡Blood vessels Clofibrate‡ • Bezafibrate • Aluminium clofibrate • Gemfibrozil • Fenofibrate • Simfibrate • Ronifibrate • Ciprofibrate • Etofibrate • Clofibride • ClinofibrateCETP inhibitors (HDL)Combinations Other Dextrothyroxine • Probucol • Tiadenol • Benfluorex • Meglutol • Omega-3-triglycerides • Magnesium pyridoxal 5-phosphate glutamate • Policosanol • Lapaquistat§ • Alipogene tiparvovecThis drug article relating to the cardiovascular system is a stub. You can help Wikipedia by expanding it.