Meglutol

Meglutol: Meglutol

Systematic (IUPAC) name

3-hydroxy-3-methylpentanedioic acid

Clinical data

Pregnancy cat. ?

Legal status ?

Identifiers

CAS number 503-49-1^Y

ATC code C10AX05

PubChem CID 1662

DrugBank DB04377

ChemSpider 1600^Y

UNII CLA99KCD53^N

KEGG D04897^Y

ChEBI CHEBI:16831^N

ChEMBL CHEMBL50444^Y

Chemical data

Formula C₆H₁₀O₅

Mol. mass 162.141 g/mol

SMILES eMolecules & PubChem

InChI

InChI=1S/C6H10O5/c1-6(11,2-4(7)8)3-5(9)10/h11H,2-3H2,1H3,(H,7,8)(H,9,10)^Y
Key:NPOAOTPXWNWTSH-UHFFFAOYSA-N^Y

N(what is this?) (verify)

Meglutol (INN, also known as 3-hydroxy-3-methylglutaric acid, β-hydroxy-β-methylglutaric acid, and dicrotalic acid) is a hypolipidemic agent.

v · d · eLipid modifying agents (C10)

GI tract

Cholesterol absorption inhibitors, NPC1L1

Ezetimibe • SCH-48461

Bile acid sequestrants/resins (LDL)

Cholestyramine • Colestipol • Colestilan • Colextran • Colesevelam

Liver

Statins (HMG-CoA reductase, LDL)

Simvastatin^# • Atorvastatin • Fluvastatin • Lovastatin • Mevastatin • Pitavastatin • Pravastatin • Rosuvastatin • Cerivastatin^‡

Niacin and derivatives (HDL and LDL)

Niceritrol • Niacin • Nicofuranose • Aluminium nicotinate • Nicotinyl alcohol • Acipimox

Blood vessels

Fibrates (PPAR)

Clofibrate^‡ • Bezafibrate • Aluminium clofibrate • Gemfibrozil • Fenofibrate • Simfibrate • Ronifibrate • Ciprofibrate • Etofibrate • Clofibride • Clinofibrate

CETP inhibitors (HDL)

Anacetrapib^† • Dalcetrapib • Evacetrapib • Torcetrapib^§

Combinations
Niacin/lovastatin • Niacin/simvastatin • Ezetimibe/simvastatin • Niacin/laropiprant

Other
Dextrothyroxine • Probucol • Tiadenol • Benfluorex • Meglutol • Omega-3-triglycerides • Magnesium pyridoxal 5-phosphate glutamate • Policosanol • Lapaquistat^§ • Alipogene tiparvovec

^#WHO-EM. ^‡Withdrawn from market. Clinical trials: ^†Phase III. ^§Never to phase III

M: MET

mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m

k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon

m(A16/C10),i(k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)

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Meglutol

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Systematic (IUPAC) name
3-hydroxy-3-methylpentanedioic acid
Clinical data
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	503-49-1^Y
ATC code	C10AX05
PubChem	CID 1662
DrugBank	DB04377
ChemSpider	1600^Y
UNII	CLA99KCD53^N
KEGG	D04897^Y
ChEBI	CHEBI:16831^N
ChEMBL	CHEMBL50444^Y
Chemical data
Formula	C₆H₁₀O₅
Mol. mass	162.141 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C6H10O5/c1-6(11,2-4(7)8)3-5(9)10/h11H,2-3H2,1H3,(H,7,8)(H,9,10)^Y Key:NPOAOTPXWNWTSH-UHFFFAOYSA-N^Y
N(what is this?) (verify)

Academic Dictionaries and Encyclopedias

Wikipedia

Meglutol

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