Clofibride

Clofibride: Clofibride

Systematic (IUPAC) name

3-(dimethylcarbamoyl)propyl 2-(4-chlorophenoxy)-2-methylpropanoate

Clinical data

Pregnancy cat. ?

Legal status ?

Pharmacokinetic data

Metabolism Hydrolyzed to clofibric acid; hepatic glucuronidation

Half-life 12 hours (clofibric acid)

Excretion Renal (mostly) and fecal

Identifiers

CAS number 26717-47-5

ATC code C10AB10

PubChem CID 160134

ChemSpider 140758^Y

UNII 0S9SLS3L93^Y

KEGG D07188^Y

Chemical data

Formula C₁₆H₂₂Cl N O₄

Mol. mass 327.803 g/mol

SMILES eMolecules & PubChem

InChI

InChI=1S/C16H22ClNO4/c1-16(2,22-13-9-7-12(17)8-10-13)15(20)21-11-5-6-14(19)18(3)4/h7-10H,5-6,11H2,1-4H3^Y
Key:CXQGFLBVUNUQIA-UHFFFAOYSA-N^Y

Y(what is this?) (verify)

Clofibride is a fibrate.

v · d · eLipid modifying agents (C10)

GI tract

Cholesterol absorption inhibitors, NPC1L1

Ezetimibe • SCH-48461

Bile acid sequestrants/resins (LDL)

Cholestyramine • Colestipol • Colestilan • Colextran • Colesevelam

Liver

Statins (HMG-CoA reductase, LDL)

Simvastatin^# • Atorvastatin • Fluvastatin • Lovastatin • Mevastatin • Pitavastatin • Pravastatin • Rosuvastatin • Cerivastatin^‡

Niacin and derivatives (HDL and LDL)

Niceritrol • Niacin • Nicofuranose • Aluminium nicotinate • Nicotinyl alcohol • Acipimox

Blood vessels

Fibrates (PPAR)

Clofibrate^‡ • Bezafibrate • Aluminium clofibrate • Gemfibrozil • Fenofibrate • Simfibrate • Ronifibrate • Ciprofibrate • Etofibrate • Clofibride • Clinofibrate

CETP inhibitors (HDL)

Anacetrapib^† • Dalcetrapib • Evacetrapib • Torcetrapib^§

Combinations
Niacin/lovastatin • Niacin/simvastatin • Ezetimibe/simvastatin • Niacin/laropiprant

Other
Dextrothyroxine • Probucol • Tiadenol • Benfluorex • Meglutol • Omega-3-triglycerides • Magnesium pyridoxal 5-phosphate glutamate • Policosanol • Lapaquistat^§ • Alipogene tiparvovec

^#WHO-EM. ^‡Withdrawn from market. Clinical trials: ^†Phase III. ^§Never to phase III

M: MET

mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m

k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon

m(A16/C10),i(k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)

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Clofibride

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Systematic (IUPAC) name
3-(dimethylcarbamoyl)propyl 2-(4-chlorophenoxy)-2-methylpropanoate
Clinical data
Pregnancy cat.	?
Legal status	?
Pharmacokinetic data
Metabolism	Hydrolyzed to clofibric acid; hepatic glucuronidation
Half-life	12 hours (clofibric acid)
Excretion	Renal (mostly) and fecal
Identifiers
CAS number	26717-47-5
ATC code	C10AB10
PubChem	CID 160134
ChemSpider	140758^Y
UNII	0S9SLS3L93^Y
KEGG	D07188^Y
Chemical data
Formula	C₁₆H₂₂Cl N O₄
Mol. mass	327.803 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C16H22ClNO4/c1-16(2,22-13-9-7-12(17)8-10-13)15(20)21-11-5-6-14(19)18(3)4/h7-10H,5-6,11H2,1-4H3^Y Key:CXQGFLBVUNUQIA-UHFFFAOYSA-N^Y
Y(what is this?) (verify)

Academic Dictionaries and Encyclopedias

Wikipedia

Clofibride

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