Colestipol

Colestipol
Colestipol
Systematic (IUPAC) name
Copolymer of N'-(2-aminoethyl)-N-[2-(2-aminoethylamino)ethyl]ethane-1,2-diamine and 2-(chloromethyl)oxirane
Clinical data
Trade names Colestid
AHFS/Drugs.com monograph
MedlinePlus a682157
Pregnancy cat.  ?
Legal status  ?
Identifiers
CAS number 50925-79-6 YesY
ATC code C10AC02
PubChem CID 62816
DrugBank DB00375
ChemSpider 56550 YesY
UNII K50N755924 YesY
KEGG C06925 N
ChEMBL CHEMBL1201678 N
Chemical data
Formula C11H28ClN5O 
Mol. mass 281.8260 g/mol
SMILES eMolecules & PubChem
 N(what is this?)  (verify)

Colestipol is a bile acid sequestrant. It works in the gut trapping bile salts, and preventing them from being reabsorbed.

This leads to decreased enterohepatic recirculation of bile salts, increased synthesis of new bile salts by the liver, decreased liver cholesterol, increased LDL receptor expression, and decreasing LDL in blood.

Side effects

Contrandications

Colestipol is contraindicated in hypotriglyceridemia.

v · d · eLipid modifying agents (C10)
GI tract
Ezetimibe • SCH-48461
Cholestyramine • Colestipol • Colestilan • Colextran • Colesevelam
Liver
Niacin and derivatives (HDL and LDL)
Blood vessels
CETP inhibitors (HDL)
Anacetrapib† • Dalcetrapib • Evacetrapib • Torcetrapib§
Combinations
Other
Dextrothyroxine • Probucol • Tiadenol • Benfluorex • Meglutol • Omega-3-triglycerides • Magnesium pyridoxal 5-phosphate glutamate • Policosanol • Lapaquistat§ • Alipogene tiparvovec

M: MET

mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m

k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon

m(A16/C10),i(k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)


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