Fluvastatin

Fluvastatin

Systematic (IUPAC) name
(3R,5S,6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid
Clinical data
Trade names	Lescol
AHFS/Drugs.com	monograph
MedlinePlus	a694010
Pregnancy cat.	?
Legal status	?
Pharmacokinetic data
Protein binding	98%
Half-life	2.5 hours
Identifiers
CAS number	93957-54-1
ATC code	C10AA04
PubChem	CID 446155
DrugBank	APRD00346
ChemSpider	393587 Y
UNII	4L066368AS Y
KEGG	D07983 Y
ChEBI	CHEBI:38565 Y
ChEMBL	CHEMBL1078 Y
Chemical data
Formula	C24H26FNO4
Mol. mass	411.466 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C24H26FNO4/c1-15(2)26-21-6-4-3-5-20(21)24(16-7-9-17(25)10-8-16)22(26)12-11-18(27)13-19(28)14-23(29)30/h3-12,15,18-19,27-28H,13-14H2,1-2H3,(H,29,30)/b12-11+/t18-,19-/m1/s1 Y Key:FJLGEFLZQAZZCD-MCBHFWOFSA-N Y
Y(what is this?)  (verify)

Fluvastatin (trade names Lescol, Canef, Vastin) is a member of the drug class of statins, used to treat hypercholesterolemia and to prevent cardiovascular disease.

It has also been shown to exhibit antiviral activity against Hepatitis C in a study with 31 patients. This effect has been described as modest, variable, and often short-lived by the authors.^[1]

References

1. ^ Bader T, Fazili J, Madhoun M, et al. (April 2008). "Fluvastatin Inhibits Hepatitis C Replication in Humans". Am. J. Gastroenterol. 103 (6): 1383. doi:10.1111/j.1572-0241.2008.01876.x. PMID 18410471. 

This drug article relating to the cardiovascular system is a stub. You can help Wikipedia by expanding it.v · Categories: Statins Diols Indoles Carboxylic acids Organofluorides Cardiovascular system drug stubs Wikimedia Foundation. 2010. Игры ⚽ Нужно сделать НИР? Panchavati Roblin, Manitoba Look at other dictionaries: Fluvastatin — Strukturformel (3R,5S,6E) Form (oben) und (3S,5R,6E) For …   Deutsch Wikipedia fluvastatin — flu·va·stat·in (flo͞o və stătʹn) n. A statin, C24H25FNO4·NA, that blocks the body s synthesis of cholesterol and is administered especially to individuals who are at risk for heart disease.   [fluoro + vastatin, statin suff.; see pravastatin.] *… …   Universalium fluvastatin — noun A drug of the statin class, used to treat hypercholesterolemia and to prevent cardiovascular disease …   Wiktionary fluvastatin — n. see statin …   Medical dictionary fluvastatin — n.; see statin …   The new mediacal dictionary fluvastatin — noun least expensive statin drug (trade name Lescol); usually taken orally at bedtime • Syn: ↑Lescol • Usage Domain: ↑trade name (for: ↑Lescol) • Hypernyms: ↑lipid lowering medicine, ↑ …   Useful english dictionary fluvastatin sodium — flu·va·stat·in so·di·um (flooґvə stat″in) [USP] an inhibitor of HMG CoA reductase, which can lower plasma levels of cholesterol and raise the plasma level of high density lipoprotein C (HDL C); used in the treatment of… …   Medical dictionary FLARE — • Fluvastatin Angioplasty Restenosis [trial] …   Dictionary of medical acronyms & abbreviations FLUENT — • Fluvastatin Long Term Extension Trial …   Dictionary of medical acronyms & abbreviations Statin — This article is about the group of cholesterol lowering drugs. For the amino acid, see Statine. Lovastatin, a compound isolated from Aspergillus terreus, was the first statin to be marketed. Statins (or HMG CoA reductase inhibitors) are a class… …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”