Bezafibrate

Bezafibrate

drugbox
IUPAC_name = 2- [4- [2- [(4-chlorobenzoyl)amino]
ethyl] phenoxy] -2-methyl-propanoic acid



width = 145px
CAS_number = 41859-67-0
ATC_prefix = C10
ATC_suffix = AB02
ATC_supplemental=
PubChem = 39042
DrugBank =
chemical_formula =
C=19 | H=20 | N=1 | I= | Br= | Cl=1 | F= | O=4 | P= | S= | Se= | Na=
molecular_weight = 361.819
bioavailability =
protein_bound =
metabolism =
elimination_half-life =
excretion =
pregnancy_category =
legal_status = RX/POM
dependency_liability = N/A
routes_of_administration = oral

Bezafibrate (Bezalip and various other brand names) is a fibrate drug used for the treatment of hyperlipidaemia. It helps to lower LDL cholesterol and triglyceride in the blood, and increase HDL.

History

Bezafibrate was first introduced by Boehringer Mannheim in 1977.

Mode of action

Like the other fibrates, bezafibrate is an agonist of PPARα; some studies suggest it may have some activity on PPARγ and PPARδ as well.

Uses

Bezafibrate improves markers of combined hyperlipidemia, effectively reducing LDL and triglycerides and improving HDL levels. [Secondary prevention by raising HDL cholesterol and reducing triglycerides in patients with coronary artery disease: the Bezafibrate Infarction Prevention (BIP) study. "Circulation" 2000;102:21-7. PMID 10880410.] The main effect on cardiovascular morbidity is in patients with the metabolic syndrome, the features of which are attenuated by bezafibrate. [Tenenbaum A, Motro M, Fisman EZ, Tanne D, Boyko V, Behar S. Bezafibrate for the secondary prevention of myocardial infarction in patients with metabolic syndrome. "Arch Intern Med" 2005;165:1154-60. PMID 15911729.] Studies show that in patients with impaired glucose tolerance, bezafibrate may delay progress to diabetes [Tenenbaum A, Motro M, Fisman EZ, Schwammenthal E, Adler Y, Goldenberg I, Leor J, Boyko V, Mandelzweig L, Behar S. Peroxisome proliferator-activated receptor ligand bezafibrate for prevention of type 2 diabetes mellitus in patients with coronary artery disease. "Circulation" 2004;109:2197-202. PMID 15123532] , and in those with insulin resistance it slowed progress in the HOMA severity marker. [Tenenbaum A, Fisman EZ, Boyko V, Benderly M, Tanne D, Haim M, Matas Z, Motro M, Behar S. Attenuation of progression of insulin resistance in patients with coronary artery disease by bezafibrate. "Arch Intern Med" 2006;166:737-41. PMID 16606809.]

ide-effects

The main toxicity is hepatic (abnormal liver enzymes), and myopathy and rarely rhabdomyolysis have been reported.

Other uses

The Australian biotech company Giaconda combines bezafibrate with chenodeoxycholic acid in an anti-hepatitis C drug combination called Hepaconda.

References


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Look at other dictionaries:

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  • bezafibrate — n. a drug that is used to treat hyperlipidaemia that fails to respond to diet (see fibrates). It is administered by mouth. Possible side effects include skin rashes, nausea and vomiting, and muscle pain. Trade name: Bezalip. * * * be·za·fi·brate… …   Medical dictionary

  • bezafibrate — n. a drug that is used to treat hyperlipidaemia that fails to respond to diet (see fibrates). It is administered by mouth. Possible side effects include skin rashes, nausea and vomiting, and muscle pain. Trade names: Bezalip …   The new mediacal dictionary

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  • Fibrate — Les fibrates sont une famille de molécules médicamenteuses utilisées pour faire baisser les lipides sanguins. Sommaire 1 Les différents fibrates 2 Effets 3 Effets secondaires 4 …   Wikipédia en Français

  • Giaconda — Infobox Company name = Giaconda logo = type = genre = foundation = 2004 founder = Thomas Borody location city = Sydney location country = Australia location = origins = key people = Patrick McLean (CEO) area served = industry = products =… …   Wikipedia

  • Bezafibrato — Saltar a navegación, búsqueda Bezafibrato …   Wikipedia Español

  • Fibratos — Saltar a navegación, búsqueda Los fibratos son sustancias químicas derivadas del ácido fíbrico (ácido clorofenoxiisobutírico). Actúan estimulando los receptores nucleares denominados “receptores activados de proliferación de los peroxisomas”… …   Wikipedia Español

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