Nerve fiber layer

Nerve fiber layer
Nerve fiber layer
Section of retina. (Stratum opticum labeled at right, second from the top.)
Plan of retinal neurons. (Stratum opticum labeled at left, second from the top.)
Latin stratum neurofibrum retinae
Gray's subject #225 1015

The retinal nerve fiber layer (nerve fiber layer, stratum opticum, RNFL) is formed by the expansion of the fibers of the optic nerve; it is thickest near the porus opticus, gradually diminishing toward the ora serrata.

As the nerve fibers pass through the lamina cribrosa sclerae they lose their medullary sheaths and are continued onward through the choroid and retina as simple axis-cylinders.

When they reach the internal surface of the retina they radiate from their point of entrance over this surface grouped in bundles, and in many places arranged in plexuses.

Most of the fibers are centripetal, and are the direct continuations of the axis-cylinder processes of the cells of the ganglionic layer, but a few of them are centrifugal and ramify in the inner plexiform and inner nuclear layers, where they end in enlarged extremities.

Patients with retinitis pigmentosa have abnormal thinning of the RNFL which correlates with the severity of the disease.[1] However the thickness of the RNFL also decreases with age and not visual acuity.[2] The sparing of this layer is important in the treatment of the disease as it is the basis for connecting retinal prostheses to the optic nerve, or implanting stem cells that could regenerate the lost photoreceptors.

RNFL is a sensitive structure. Some process can excites its natural apoptosis. Harmful situation can make some damage on RNFL such as high intraocular pressure, high fluctuation on phase of intraocular pressure, inflammation, vascular disease and any kind of hypoxia. Gede Pardianto (2009) reported 6 cases of RNFL thickness change after the procedures of phacoemulsification.[3]


  1. ^ Walia S, Fishman GA, Edward DP, Lindeman M. Retinal nerve fiber layer defects in RP patients. Invest Ophthalmol Vis Sci. 2007 Oct;48(10):4748-52. PMID: 17898300
  2. ^ Oishi A, Otani A, Sasahara M, Kurimoto M, Nakamura H, Kojima H, Yoshimura N. Retinal nerve fiber layer thickness in patients with retinitis pigmentosa. Eye. 2008 Mar 14, online advance publication. PMID: 18344951
  3. ^ Pardianto G, Mastering phacoemulsification in Mimbar Ilmiah Oftalmologi Indonesia.2009;10:26.

External links

This article was originally based on an entry from a public domain edition of Gray's Anatomy. As such, some of the information contained within it may be outdated.

Wikimedia Foundation. 2010.

Игры ⚽ Поможем сделать НИР

Look at other dictionaries:

  • nerve fiber layer of retina — a layer of the stratum nervosum retinae, situated between the ganglion cell layer and the internal limiting membrane, consisting essentially of the axons of the ganglion cells which pass through the lamina cribrosa to form the optic nerve. In… …   Medical dictionary

  • olfactory nerve fiber layer — the outermost layer of the olfactory bulb, composed of axons of the olfactory cells before they terminate in the adjacent glomerular layer …   Medical dictionary

  • Nerve — A bundle of fibers that uses electrical and chemical signals to transmit sensory and motor information from one body part to another. See nervous system. * * * A whitish cordlike structure composed of one or more bundles (fascicles) of myelinated …   Medical dictionary

  • Outer nuclear layer — Section of retina. (Outer nuclear layer labeled at right, fourth from the bottom.) …   Wikipedia

  • Outer plexiform layer — Section of retina. (Outer plexiform layer labeled at right, sixth from the top.) …   Wikipedia

  • Optic nerve tumor — An optic nerve melanocytoma is a tumor made up of melanocytes and melanin. These tumors are typically a benign; they can grow, but rarely transform into a malignancy. Even so, local growth can affect adjacent tissues. Symptoms Optic nerve… …   Wikipedia

  • ganglion cell layer of retina — a layer of the stratum nervosum retinae, situated between the inner plexiform layer and the nerve fiber layer, consisting essentially of the ganglion cells of the retina, and containing also the MÑŒller fibers, neuroglia, and branches of the… …   Medical dictionary

  • glomerular layer — the layer of the olfactory bulb between the olfactory nerve fiber layer and the external granular layer, containing the olfactory glomeruli …   Medical dictionary

  • Fiber — The parts of plants that cannot be digested, namely complex carbohydrates. Also known as bulk or roughage. Complex carbohydrates from plants are rich in starch and fiber. Examples of plants that provide complex carbohydrates (fiber) are fresh… …   Medical dictionary

  • Nerve guidance conduit — A nerve guidance conduit (also referred to as an artificial nerve conduit or artificial nerve graft, as opposed to an autograft) is an artificial means of guiding axonal regrowth to facilitate nerve regeneration and is one of several clinical… …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”