Coumermycin A1

Coumermycin A1

Systematic (IUPAC) name
[(3R,4S,5R)-5-Hydroxy-6-[2-hydroxy-3-[[4-[[2-hydroxy-7-[(3R,4S,5R)-3-hydroxy-5-methoxy-6,6-dimethyl-4-(5-methyl-1H-pyrrole-2-carbonyl)oxyoxan-2-yl]oxy-8-methyl-4-oxochromen-3-yl]carbamoyl]-3-methyl-1H-pyrrole-2-carbonyl]amino]-8-methyl-4-oxochromen-7-yl]oxy-3-methoxy-2,2-dimethyloxan-4-yl] 5-methyl-1H-pyrrole-2-carboxylate
Clinical data
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	4434-05-3 Y
ATC code	None
PubChem	CID 451651
ChEMBL	CHEMBL555830 N
Synonyms	Coumamycin
Chemical data
Formula	C55H59N5O20
Mol. mass	1110.08 g/mol
SMILES	eMolecules & PubChem
N(what is this?)  A1 (verify)

Coumermycin A1 is an aminocoumarin.^[1][2]

References

1. ^ Heide, L. (2009). "Genetic engineering of antibiotic biosynthesis for the generation of new aminocoumarins". Biotechnology advances 27 (6): 1006–1014. doi:10.1016/j.biotechadv.2009.05.017. PMID 19463934.  edit
2. ^ Heide, L.; Gust, B.; Anderle, C.; Li, S. M. (2008). "Combinatorial biosynthesis, metabolic engineering and mutasynthesis for the generation of new aminocoumarin antibiotics". Current Topics in Medicinal Chemistry 8 (8): 667–679. doi:10.2174/156802608784221505. PMID 18473891.  edit

Other/ungrouped

sulfanilamide (Sulfacetamide, Sulfametrole)

Combinations

Trimethoprim/sulfamethoxazole^#

Topoisomerase
inhibitors/
quinolones/
(inhibits
DNA replication)

1st g.	Cinoxacin‡ • Flumequine • Nalidixic acid • Oxolinic acid • Pipemidic acid • Piromidic acid • Rosoxacin
Fluoro- quinolones	2nd g. Ciprofloxacin#  • Enoxacin‡ • Fleroxacin‡ • Lomefloxacin • Nadifloxacin • Ofloxacin • Norfloxacin • Pefloxacin • Rufloxacin 3rd g. Balofloxacin • Grepafloxacin‡ • Levofloxacin • Pazufloxacin • Sparfloxacin‡ • Temafloxacin‡ • Tosufloxacin 4th g. Besifloxacin • Clinafloxacin† • Garenoxacin • Gemifloxacin • Moxifloxacin • Gatifloxacin‡ • Sitafloxacin • Trovafloxacin‡/Alatrofloxacin‡ • Prulifloxacin Vet. Danofloxacin • Difloxacin • Enrofloxacin • Ibafloxacin • Marbofloxacin • Orbifloxacin • Pradofloxacin • Sarafloxacin Related (DG) Aminocoumarins: Novobiocin

Anaerobic DNA
inhibitors

Nitro- imidazole derivatives	Metronidazole#  • Tinidazole • Ornidazole
Nitrofuran derivatives	Nitrofurantoin#  • Furazolidone‡  • Nifurtoinol

RNA synthesis

Rifamycins/ RNA polymerase

Rifampicin • Rifabutin • Rifapentine • Rifaximin

^#WHO-EM. ^‡Withdrawn from market. Clinical trials: ^†Phase III. ^§Never to phase III

M: BAC bact (clas) gr+f/gr+a(t)/gr-p(c)/gr-o drug(J1p, w, n, m, vacc)