Clorobiocin

Clorobiocin

Systematic (IUPAC) name
[(3R,4S,5R,6S)-6-[8-Chloro-2-hydroxy-3-[[4-hydroxy-3-(3-methylbut-2-enyl)benzoyl]amino]-4-oxochromen-7-yl]oxy-5-hydroxy-3-methoxy-2,2-dimethyloxan-4-yl] 5-methyl-1H-pyrrole-2-carboxylate
Clinical data
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	39868-96-7 Y
ATC code	None
PubChem	CID 73622
ChEMBL	CHEMBL303984 N
Synonyms	Chlorobiocin
Chemical data
Formula	C35H37ClN2O11
Mol. mass	697.13 g/mol
SMILES	eMolecules & PubChem
N(what is this?)  (verify)

Clorobiocin is an aminocoumarin.^[1][2]

References

1. ^ Pojer, F.; Wemakor, E.; Kammerer, B.; Chen, H.; Walsh, C.; Li, S.; Heide, L. (2003). "CloQ, a prenyltransferase involved in clorobiocin biosynthesis". Proceedings of the National Academy of Sciences of the United States of America 100 (5): 2316–2321. Bibcode 2003PNAS..100.2316P. doi:10.1073/pnas.0337708100. PMC 151338. PMID 12618544. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=151338.  edit
2. ^ Heide, L. (2009). "Genetic engineering of antibiotic biosynthesis for the generation of new aminocoumarins". Biotechnology advances 27 (6): 1006–1014. doi:10.1016/j.biotechadv.2009.05.017. PMID 19463934.  edit

Other/ungrouped

sulfanilamide (Sulfacetamide, Sulfametrole)

Combinations

Trimethoprim/sulfamethoxazole^#

Topoisomerase
inhibitors/
quinolones/
(inhibits
DNA replication)

1st g.	Cinoxacin‡ • Flumequine • Nalidixic acid • Oxolinic acid • Pipemidic acid • Piromidic acid • Rosoxacin
Fluoro- quinolones	2nd g. Ciprofloxacin#  • Enoxacin‡ • Fleroxacin‡ • Lomefloxacin • Nadifloxacin • Ofloxacin • Norfloxacin • Pefloxacin • Rufloxacin 3rd g. Balofloxacin • Grepafloxacin‡ • Levofloxacin • Pazufloxacin • Sparfloxacin‡ • Temafloxacin‡ • Tosufloxacin 4th g. Besifloxacin • Clinafloxacin† • Garenoxacin • Gemifloxacin • Moxifloxacin • Gatifloxacin‡ • Sitafloxacin • Trovafloxacin‡/Alatrofloxacin‡ • Prulifloxacin Vet. Danofloxacin • Difloxacin • Enrofloxacin • Ibafloxacin • Marbofloxacin • Orbifloxacin • Pradofloxacin • Sarafloxacin Related (DG) Aminocoumarins: Novobiocin

Anaerobic DNA
inhibitors

Nitro- imidazole derivatives	Metronidazole#  • Tinidazole • Ornidazole
Nitrofuran derivatives	Nitrofurantoin#  • Furazolidone‡  • Nifurtoinol

RNA synthesis

Rifamycins/ RNA polymerase

Rifampicin • Rifabutin • Rifapentine • Rifaximin

^#WHO-EM. ^‡Withdrawn from market. Clinical trials: ^†Phase III. ^§Never to phase III

M: BAC bact (clas) gr+f/gr+a(t)/gr-p(c)/gr-o drug(J1p, w, n, m, vacc)